药物代谢酶类多态性与药物作用个体差异
摘要
药物代谢酶类多态性与药物作用个体差异谢文天（浙江省天台县人民医院３１７２００）陈枢青（浙江医科大学基础医学院）１药物代谢酶类多态性是造成药物作用个体差异的原因之一药物代谢酶类的天然意义是为了代谢外来化合物，通过第一相反应氧化、还原和水解，以及第二相结...
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第3期128-129,共2页
Chinese Journal of Hospital Pharmacy
参考文献14
-
1Agarwal DP ,Goedde HW. Pharmacogenetics of alcohol metabolism and alcholism, Pharmacogeneties,1992,2:48.
-
2Shah RR,Oates N,ldle JR,et al.Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.Br Med J,1982,284:295.
-
3Funck-Rrentano C,Kroemer HK,Lee JT,et al.Drug therapy-propafenone.N Eng J Med,1990,322:518.
-
4Chen S,Chou WH,Blouin PA,et al.The eytochrome P450 2D6(CYP2D6)enzyme polymorphism:Sereening coats and influence on clinical outcomes in psychiatry.Clinical Pharmacology and Therapeuties,1996,60:522.
-
5Maghoub A,Idle JR,Ring LG,et al.Polymorphic hydroxylation of debrisoquine in man.Lancet,1977,2:584.
-
6Yoshida A,Molecular genetics of human aldehyde dehydrogenase.Pharmacogenet,1992,2:139.
-
7Hajra A,Sorenson RC,La Du BN,Detcction of human DNA mutions with nonradioactive allele-specific oligonucleotide probes.Pharmacogenet,1992,2:78.
-
8Seidergard J,Voracek WR,Pero RW,et al.Hereditary differences in the expression of the human glutatione Stransferase active on trans-stilbene oxide are due to gene deletion.Proc Natl Acad Sci USA,1988,45:7293.
-
9Rothman N,Hayes RB,Bi W,et al.Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males.Pharmacogenet,1993,3:250.
-
10Weber WW,Vatsis RK,Individual variability in P-amin obenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood.Pharmacogenet,1993,3:209.
