应用无复发生存率和无远处转移生存率进行肿瘤预后的评价——附411例鼻咽癌资料分析

FLF and FDM in prognostic research of cancer ——Analysis of 411 cases of nasopharyngeal carcinoma (NPC)

目的：阐述无复发生存率（ＦＬＦ）和无远处转移生存率（ＦＤＭ）在肿瘤预后研究中的重要性和必要性。方法：４１１例初次放射治疗的鼻咽癌病例资料纳入研究，以生存率、无复发生存率和无远处转移生存率为预后指标，通过ＣＯＸ比例风险模型，分析比较影响鼻咽癌生存、复发和远处转移的因素。结果：与生存有关的因素为性别，’９２分期，Ｎ分期，颈部射线；放射治疗后鼻咽肿瘤残留与鼻咽复发存在密切关系，与远处转移密切相关的因素是Ｎ分期。结论：只有应用无复发生存率（ＦＬＦ）和无远处转移生存率（ＦＤＭ）为指标，才能明确影响肿瘤复发的因素和转移的因素，这两个指标在评价治疗措施和肿瘤分期研究中均有意义。

Purpose: To demonstrate the importance and necessity of the free from localregional failure survival rate (FLF) and free from distant metastasis survival rate (FDM) in prognostic research of cancer. Methods: 411 cases of NPC, treated with initial radiotherapy, entered this study. The factors of influencing survival, relapse and distant metastasis were analyzed by means of Cox model with the survival rate, FLF and FDM were used as prognostic indexes. Results: The prognostic factors of survival were sex, '92 stage, N stage and irradiation dose for the neck; the tumor resident in nasopharynx was closely relative to local control failure; and the factor of predicting distant metastasis was N stage. Conclusion: Only the use of prognostic indexes such as FLF and FDM can clearly undertand the factors influencing relapse and metastasis. The FLF and FDM showed significance in evaluation of therapeutics and staging system for cancer.