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聚合酶链反应检测肺下叶结核支气管灌洗液中结核菌的对比分析

DIAGNOSTIC VALUE OF PCR MEASURING THE BRONCHIAL LAVAGES FOR PULMONARY INFERIOR LOBE TUBERCULOSIS
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摘要 为探讨支气管灌洗液结核PCR检测对下叶肺结核诊断价值。采用支气管灌洗液PCR与结核杆菌培养、涮检、病检以及血中结核抗体、皮肤PPD试验作对比分析。结果显示,结核组支气管灌洗液PCR阳性率80%,涮检涂片36%、活检12%、培养32%。PCR法明显优于其它三种。χ2检验P<0.01,肺结核组涮检涂片阳性、PCR法同样阳性。血清结核抗体阳性率68%,高于皮肤PPD试验阳性率的32%,结核抗体阳性者PCR法均阳性。结论:支气管灌洗液PCR检测是下叶肺结核早期快速诊断的一种有价值检测手段。 Polymerase chain reaction (PCR) was applied to detect DNA of Mycobacterium tuberculosis in 25 TB and 23 NonTB cases,using bronchial lavage fluids from inferior lobes as the sample;the result of PCR measurement was analytically compared with that of conventional procedures.It was found that in the 25 TB cases the positive rates of bronchial acidfast staining,culture,biopsy,and PCR were 36%,32%,12%,and 80% respectively.The sensitivity of PCR was much higher than the other′s(P<001).Acidfast staining was postive just the same as PCR.PCR will prove positive as long as the antibody against TB in blood shows positive;positive rate of the antibody is 68%,being higer than that of skin PPD (32%).Conclusion:PCR measurement of bronchial lavages is a rapid,sensitive,and valuable procedure for the diagnosis of pulmonary inferior lobe tuberculosis.
作者 张玲 赵宪玲
出处 《山西医药杂志》 CAS 1998年第2期103-104,共2页 Shanxi Medical Journal
关键词 肺下叶结核 结核杆菌 聚合酶链反应 pulmonary inferior lobe tuberculosis Mycobacterium tuberculosis polymerase chain reaction (PCR)
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参考文献5

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