高海拔地区胆囊切除术麻醉镇痛血浆神经肽Y变化及其临床意义

Perioperative Change of Plasma Neuropeptide Y in Patients Undergoing Cholecystectomy at High Altitude Areas

目的高海拔地区胆囊切除患者围术期血浆神经肽Y(NPY)水平的变化。方法用放射免疫法测定30例高海拔地区胆囊切除患者术前、术中及术后不同时期血浆NPY浓度。结果与术前比较,术中及术后24h血浆NPY明显下降,(P<0.05)。结论良好镇痛可有效降低围术期应激反应的程度,减轻手术对机体免疫反应的干扰,尤其术后镇痛更明显。

Objective To observe the perioperative change of plasma neuropeptide Y （NPY） in patients undergoing cholecystectomy. Methods The plasma NPY of thirty patients was measured before, during and after operation by radioimmunassay. Results The plasma NPY level descend significantly during and 24 h after operation （p〈0.05）. Conclusion Analgesia can depress perioperative stress response effectively, particularly the postoperative 24 h in analgesia NPY level descend more obviously.