^(18)F-FDG符合线路正电子显像对肺癌的诊断价值研究

Diagnostic Value of ^(18)F-FDG Coincidence PET on Lung Cancer

目的探讨18F-FDG符合线路正电子显像对肺癌的诊断价值。方法利用双探头符合线路SPECT对105例可疑肺癌患者进行18F-FDG正电子显像,并进行同机CT图像融合。利用感兴趣技术计算病变与对侧正常部位的放射性计数比值(T/NT)对病灶进行半定量分析,比较视觉分析和半定量分析18F-FDG符合线路正电子显像对肺癌的诊断效能。结果视觉分析对肺癌的诊断灵敏度为92.13%,特异性为56.25%,准确性为86.66%。以T/NT≥2.7为判断阈值,半定量分析的灵敏度为95.5%,特异性为81.3%,准确性为93.3%。结论18F-FDG符合线路正电子显像视觉分析结合半定量分析对肺癌的诊断具有较高的灵敏度、特异性和准确性,可应用于肺癌的诊断和鉴别诊断。

Objective To investigate the diagnostic value of ^18F-FDG coincidence PET on lung cancer. Methods ^18F-FDG PET imaging was performed on 105 patients suspecte.d lung cancer with dual-head coincidence SPECT device. Visual analysis and semi-quantitative method with ROI were performed on lung lesions of ^18 F-FDG uptake. Target to no-target active ratio （T/NT） of lung lesions were calculated. Results With visual analysis, the diagnostic sensitivity, specificity and accuracy of ^18 F-FDG coincidence imaging were 92.13%, 56.25%, 86.66%, respectively. With semi-quantitative analysis, the diagnostic sensitivity, specificity and accuracy of ,^18-FDG coincidence imaging were 95.5%, 81.3% and 93.3%, respectively according to T/NT≥2.7 threshold. Conclusion ^18F-FDG coincidence PET imaging based on visual analysis and semi-quantitative analysis has high diagnostic sensitivity, specificity and accuracy for lung cancer, ^18 F-FDG coincidence PET imaging is useful in diagnosis and differential diagnosis of lung cancer.