摘要
①目的观察牛磺酸对大鼠杏仁核点燃进程的影响。②方法将杏仁核植入电极的大鼠分为生理盐水组（对照组）和牛磺酸组，对照组脑室内注射生理盐水，牛磺酸组脑室内注射牛磺酸，注射容积均为每只２０μｌ，电刺激大鼠右侧杏仁核，每天１次，记录脑电和后放电时间，观察大鼠癫痫发作表现。③结果对照组大鼠在１３．２±４．２次被全部点燃，而牛磺酸组仅２只被点燃，两组点燃大发作率差异有显著性（Ｐ＝０．００３５）。此时停止给牛磺酸，继续刺激未被点燃的大鼠，最终在２１．９±７．２次被点燃，两组间差异有显著性（ｔ＝２．９５，Ｐ＜０．０１）。
Objective To obseve the effect of taurine on the development of amygdala kindling in rats. Methods Rats with electrode implanted into their amgydalas were divided into two groups:control group(i.c.v. injection of 20μl N.S) and taurine group(i.c.v. injection of 20μl taurine). Electrical stimulation of the right amgydala (400μA, 60Hz, square wave for one sec) was given once a day. EEG and after discharge duration were recorded and seizure severity was observed. Results All rats in the control group were kindled at the 13. 23±4. 2 times of electrical stimulation . Only two rats in taurine group were kindled. The rate of kindling showed significant differences between the two groups( P =0.0035). Ceasing of taurine injection for the unkindled rats in taurine group while continuing the stimulating , the rats were finally kindled at 21.9±7.2 times of electrical stimulation. There were significant differences between the two groups( t=2.95,P< 0. 01) . Conclusion Taurine had inhibitory effect on the development of amgydala kindling in rats.
出处
《青岛医学院学报》
1998年第1期4-5,共2页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省卫生厅科研基金
