摘要
①目的探讨雌激素受体（ＥＲ）与胃腺癌的发生及其生物学行为之间的关系。②方法应用葡聚糖包裹活性炭饱和分析法，检测了４０例胃腺癌及其远隔胃粘膜组织中ＥＲ的含量。③结果４０例胃癌组织中７例ＥＲ阳性，含量为１５５．４±９１．０ｆｍｏｌ／ｍｇ蛋白；而远隔胃粘膜组织中未检测到ＥＲ；胃癌组织中ＥＲ阳性率及含量均显著高于远隔粘膜组织（Ｐ＝０．０１；ｔ＝１１．４，Ｐ＜０．０１）。ＥＲ阳性率与胃癌病人的年龄、性别、Ｂｏｒｒｍａｎ分型、肿瘤大小及细胞分化程度，在不同分组间差异均无显著意义（χ２＝０．０６～１．５４，Ｐ均＞０．０５）。
Objective To study the relationship between estrogen receptors (ER) and the biological behavior and development of gastric adenocarcinoma. Methods ER content was measured in 40 cases of gastric adenocarcinoma and their corresponding paracancerous gastric tissues using dextran coated charcoal method. Results ER was detected in 7 out of 40 patients with gastric carcinoma, with average value of 155. 4 ± 91. 0 fmol/mg protein; but ER was not found in paracancerous gastric tissues.Positive rate and contents of ER in gastric adenocarcinoma was significantly higher than that in paracancerous tissues( P= 0.01, t=11.4,P <0.01) . ER positive rate in gastric carcinoma was not correlated with age,sex,Borrman type,size of the tumor and histological grade ( χ 2=0.06～1.54,P >0.05). Conclusion ER had important value on carcinogenesis of gartric tissue.
出处
《青岛医学院学报》
1998年第1期32-33,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
胃肿瘤
受体
雌激素
腺癌
DCC法
gastric neoplasms
estrogen receptor
dextran coated charcoal
