家兔心肌缺血再灌注损伤及川芎嗪保护作用的超微结构改变

Ultrastructural changes of myocardial ischemia-reperfusion injury in rabbits and protective effects of liqustrazin

了解川芎嗪在心肌缺血再灌注损伤中对心肌细胞的保护作用。方法应用电镜观察家兔心肌缺血再灌注损伤及经川芎嗪保护的形态改变。结果川芎嗪保护组在线粒体肿胀、肌原纤维与肌膜损伤等方面的变化明显轻于非保护组。结论川芎嗪具保护心肌细胞生物膜及其结构完整性，减轻缺血再灌注心肌细胞损害的作用。

Objective To study the ultrastructure changes of myocardial ischemia-reperfusion injury in rabbits and the ef- fects of liqustrazin. Methods Morphological changes of myocardial ischemia-reperfusion in rabbits and the protective effects of liqustrazin were observed under electron microscope. Results , Damage of the protected group with liqustrazin was significantly less than that of the nonprotected group in mitochondrion . myofibrils and myomenbrane Conclusion : Liqustrazin can protect myocardial cell biomembrane and its structural integrity and decrease the injury after ischemia reperfusion myocardium .