多措施干预治疗新生儿缺氧缺血性脑病的临床研究

The clinical study of GM-I,HBO and convalescent drilling in hypoxic-ischemic encephalopathy of newborn

目的探讨神经节苷脂、高压氧、康复训练联合治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将确诊为HIE的中、重度患儿112例随机分为两组,干预组采用神经节苷脂、高压氧及康复训练治疗,对照组仅采用神经节苷脂治疗。所有患儿于3、6、12、24个月时进行智能运动发育检测。结果24个月时干预组与对照组智能发育指数(MDI)分别为92.59±13.70和81.76±13.99,运动发育指数(PDI)分别为97.52±14.06和88.66±12.19。24个月时两组患儿MDI、PDI异常、脑瘫、精神发育迟滞发病例数分别为5和12,7和15,3和10,2和9。结论对HIE患儿进行定期随访并给予早期干预治疗,确能有效地促进智能及运动发育,是改善预后、降低后遗症发生率的有效手段。

Objective： To explore the effect of using GM-Ⅰ, HBO and convalescent drilling in treating Hypoxic-ischemic encephalopathy （HIE） . Methods： 112 cases with moderate and severe HIE were divided into two groups at random： the observe group and the control group. The observe group were treated with irritate of brain cells, HBO, and convalescent drilling; while the patients of the control group used regular mothercraft and GM-Ⅰ. All the patients were tested in the Intelligence Quotient（IQ） when they were three, six,twenty-four months old. Results： MDI of the observation group and the control group were respectively 92.59 ± 13.70 and 81.76 ± 13.99 ;the PDI of the two groups were respectively 97.52 ± 14. 06 and 88.66 ± 12.19. The MDI, PDI abnormity, cerebral palsy （CP） , MR of the two groups were respectively 5 and 12;7 and 15; 3 and 10; 2 and 9 when they were twenty-four months old. Conclusion： Following and interfering method about HIE patients can surely accelerate the intelligent and physical development. It is an effective method to reduce incidence of sequelae in HIE.