摘要
观察了单脉冲低频率电刺激大鼠纹状体（ＣＰｕ）和黑质网状部（ＳＮＲ）注射Ｐ物质（ＳＰ，２．５μｇ／０．０５μｌ），对丘脑腹内侧核（ＶＭ）自发放电频率的影响。结果是：（１）电刺激ＣＰｕ使大多数ＶＭ神经元兴奋（１６／１８）；（２）ＳＮＲ注ＳＰ使大多数神经元抑制（１５／１９）；（３）大多数神经元（１１／１５）对电刺激ＣＰｕ表现兴奋的同时，对ＳＮＲ注ＳＰ表现抑制。提示电刺激ＣＰｕ触发了纹体—黑质ＧＡＢＡ的释放，ＧＡＢＡ与ＳＰ在黑质水平共同调节黑质—ＶＭＧＡＢＡ通路，前者抑制，后者兴奋。
The effects of caudate putamen (CPu)monopulse low-frequency electrical stimulation and unilateral microinjection of substance P(SP,2.5μg/0.05μl)into the substantia nigra reticulata (SNR) on the spontaneons firings of the thalamic ventromedical(VM) cell in rat were observed.The findings are as follows:(1) CPu stimulations excited major VM cells(16/18).(2)intranigral SP inhibited major VM cells(15/19).(3)mojor VM cells(11/15)were not only excited by CPu stimulation but also inhibited by intranigral SP. The result indicates that SP and GABA together provides regulation for the nigrothalamic GABA projection to the VM,SP excitement whereas GABA inhibition.
出处
《锦州医学院学报》
1998年第1期1-3,共3页
Journal of Jinzhou Medical College
关键词
电刺激
CPu
SNR
P物质
丘脑腹内侧核
GABA
electrical stimulation
caudate putamen
snbstantia nigra reticulata
substauce P
thalamic ventromedical nucleu
spontaneons firing
