摘要
23例结直肠癌术前未用消炎痛肛塞治疗的非用药组,外周静脉,局部灌流动静脉血的CD_4^+/CD_8^+值下降,SIL-2R、PGE_2水平升高,Dukes D期患者免疫功能显著异常。术前用消炎痛肛塞的用药组CD_4^+/CD_8^+值较非用药组增高,SIL-2R、PGE_2水平下降,Dukes C、D期患者局部灌流动静脉的各项免疫指标显著改善。说明结直肠癌患者免疫功能下降,晚期更受损,使用消炎痛肛塞可提高中晚期患者的局部免疫功能。
The ralio between CD4+ and CD8+ decreased in the peripheral venous blood and the neoplasraa arterial and venous blood while SIL - 2R and PGE2 level raised in 23 patients with coloreclal cancer without administrating indomethacin before operation . The immunity during Dukes Stage patients is abnormal Significantly . The ration between CD4+ and CD8+ in patients administrating indomethacin before operation was higher than that in patients without administrating indomethacin while SIL -2R and PGE2 level lowered . During Dukes C and D stage it was found that various immunity was improved shown by various immunity indexes determinated from the arterial and venous blood obtained by neoplasma perfusion . These suggested that immunological function in patients with colorectal cancer reduced . The immunological function during Dukes D stage even reduced more. Indomethacin may enhance the local immunity during Dukes C and D stage in patients with colorectal cancer patients .
出处
《苏州医学院学报》
1998年第4期355-357,共3页
Acta Academiae Medicinae Suzhou
关键词
结直肠肿瘤
CRC
免疫功能
消炎痛
colorectal cancer
indomethacin
T cell subsets
soluble inteleukin - 2 receptor
prostaglandin E_2
