摘要
1例46岁女性患者,因结核性胸膜炎入院,给予口服利福平450mg,1次/d、异烟肼300mg,1次/d、吡嗪酰胺500mg,3次/d、乙胺丁醇750mg,1次/d治疗。患者治疗前血小板为335×109/L,用药14d后血小板下降至1.8×109/L,四肢及腹部皮肤出现较密集的出血点和瘀斑。停用利福平,给予输注血小板和甲泼尼龙治疗,其他治疗维持不变。1周后血小板升至164.2×109/L。
A 46-year-old woman was hospitalized with tuberculous pleurisy. She was treated orally with rifampicin 450 mg once daily, isoniazid 300 mg once daily, pyrazinamide 500 mg thrice daily, and ethambutol 750 mg once daily. Her platelet count was 335 x 109/L before treatment. After 14 days of therapy, her platelet count decreased to 1.8 x 109/L, and the dense bleeding points and ecchymoses occurred on her skin of extremities and abdomen. Rifampicin was withdrawn, and platelet transfusion and methylprednisolone treatment was given. The other therapy remained unchanged. One week later, her platelet count increased to 164. 2 x 109/L.
出处
《药物不良反应杂志》
2008年第6期441-442,共2页
Adverse Drug Reactions Journal
关键词
利福平
血小板减少
不良反应
rifampicin
thrombocytopenia
adverse reaction
