泛昔洛韦致头晕和胃肠反应

Dizziness and gastrointestinal reaction induced by famciclovir

1例63岁女性,糖尿病史4月,口服格列吡嗪和阿卡波糖治疗,一直无不良反应。后因患单纯疱疹给予泛昔洛韦0.25g,3次/d口服。首次用药2h后即出现头晕、恶心、呕吐、腹痛、腹泻,粪便检查排除肠道感染。停用泛昔洛韦,改用阿昔洛韦0.5g,1次/d静脉滴注,格列吡嗪和阿卡波糖继续服用,同时给予补液及对症治疗,第2天头晕和胃肠反应症状完全消失。继续静脉滴注阿昔洛韦4d,单纯疱疹全部结痂,患者痊愈出院。

A 63-year-old woman with a 4-month history of diabetes took glipizide and aearbose without adverse reactions occurring. Later, the woman received oral famciclovir 0.25 g thrice daily for herpes simplex. Two hours after the first administration, she experienced dizziness, nausea, vomiting, abdominal pain, and diarrhea. Intestinal infection was excluded by stool examination. Famciclovir was withdrawn and switched to an IV infusion of aciclovir 0.5 g once daily. Glipizide and acarbose were continued. Meanwhile, fluid replacement and symptomatic therapy were given. The following day, her dizziness and gastrointestinal symptoms disappeared completely. The patient continuously received IV infusion of aciclovir for four days. Her herpes simplex was entirely crusted and she was fully cured and discharged.