Celluvisc治疗角膜上皮病变的初步报告

TX The preliminary observation of celluvisc for the treatment of corneal epithialdiseases

为评价Ｃｅｌｕｖｉｓｃ治疗角膜上皮病变的效果，采用前瞻性研究，将３４例５７眼角膜上皮病变患者随机分为Ｃｅｌｕｖｉｓｃ治疗组（１７例２９眼）及ＳｏｌｏｃｏｓｅｒｙＥｙｅ－ｇｅｌ对照组（１７例２８眼），观察两组的治疗效果。结果：经４周的治疗及随访，治疗组２９眼均有效，其中９眼治愈，２０眼好转。对照组有２１眼有效，其中５眼治愈，１６眼好转，无效７眼，均为干眼症患者，且经应用Ｃｅｌｕｖｉｓｃ治疗后好转。在点状角膜炎及角膜上皮缺损组，两组的治愈率与好转率经统计学处理无显著差异（Ｘ２检验，Ｘ２＝１．２０８，Ｐ＞０．２５）。但在泪液分泌不足的干眼症组，治疗组的好转率明显高于对照组（Ｘ２检验，Ｘ２＝９．９７５，Ｐ＜０．００５）。结论：Ｃｅｌｕｖｉｓｃ治疗角膜上皮病变安全、有效，尤其适用于治疗干眼引起的角膜上皮病变。

urpose To evaluate the effect of Celluvisc for the treatment of corneal epithial diseases.Methods The 34 patients(57 eyes)with corneal epithial diseases were enrolled in this study.The patients were divided into group one(17 cases,29 eyes)treated with Celluvisc and group two(17 cases,28 eyes)treated by Solocosery Eyegel.The effect was observed and compared between two groups.Results All patients were treated and followed for four weeks.The 29 eyes in group one were effective,with 9 eyes were cured.21 eyes in group two were effective,with 5 eyes were cured.And the another 7 eyes suffer with dry eye were noeffective,which were improved by Celluvise.The cured and improved rate between two groups were no different in statistics(X2=1208,P>025)in punctual keratitis and corneal defe ct.The symptoms and fluorescein staining in group one were significent improvement than that in group two (X2=9975,P<0005)Conclusion The Celluvisc is a effective and safe drug in treatment of corneal epithial diseases.And it is the one of the best eyedrops to treat corneal epithial abnormal induced by dry eye.