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决奈达隆:治疗房颤的新型抗心律失常药 被引量：7

Dronedarone:a novel antiarrhythmic drug for the treatment of atrial fibrillation
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摘要 决奈达隆为不含碘的苯并呋喃类衍生物,其结构和特征与胺碘酮类似,但减少了碘源性的器官毒性,目前已经完成动物实验和部分临床试验。研究结果表明,在房颤患者中应用决奈达隆800 mg/d安全而有效,不良反应少。 Dronedarone is a noniodinated benzofurane derivative, which is structurally and characteristically similar to amiodarone. It has been developed to overcome the iodine-associated adverse effects of amiodarone. The animal experiments and several clinical trials have been accomplished. The clinical trials indicated efficacy,safety and low adverse reactions of dronedarone （800 mg/d） in patients with atrial fibrillation.
作者 刘璟 秦永文
机构地区 第二军医大学长海医院心血管内科
出处 《药学服务与研究》 CAS CSCD 2008年第6期417-420,共4页 Pharmaceutical Care and Research
关键词 决奈达隆 胺碘酮 心房颤动 心律失常 综述 dronedarone amiodarone atrial fibrillation arrhythmia review
分类号 R972.2 [医药卫生—药品]
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参考文献17

  • 1Dale K M, White C M. Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter[J]. Ann Pharmacother, 2007,41 (4): 599-605.
  • 2Lalevee N, Nargeot J, Barrere-Lemaire S, et al. Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes[J]. J Cardiovasc Electrophysiol,2003,14(8): 885-890.
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同被引文献33

  • 1张杰,张楠,葛海涛.心房颤动治疗药物决奈达隆[J].世界临床药物,2009,30(12):765-768. 被引量：5
  • 2杨世磊,戴晓健,汤新强,钟大放,陈笑艳.犬血浆中决奈达隆及其代谢物SR35021的LC-MS/MS法测定[J].中国医药工业杂志,2011,42(7):525-528. 被引量：4
  • 3吕峰,刘玉婷,邹竞,张大德,姚祖光.DIAR黄成色剂的合成[J].华东理工大学学报（自然科学版）,2005,31(2):180-183. 被引量：2
  • 4杨利民.一种决奈达隆关键中间体的新的制备方法:中国,101153012[P].2008-04-02.
  • 5ChP(中国药典).2010.VolⅡ(二部):922.
  • 6Walsh S.FDA approves Multaq to treat heart rhythm disorder[EB/OL].[2009-07-021.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm 170276.htm.
  • 7Gubin J,Lucchetti J,Inion H,et al.Preparation of benzofurans,benzothiophenes,indoles,and indolizines as cardiovascular agents:EP,471609[P].1992-12-19.(CA 1992,117:26336).
  • 8Biard M.2-Butyl-3-(4-[3-(dibutylamino) propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof.WO,2002048078[P].2002-06-20.(CA 2002,137:33204).
  • 9Gutman AL,Nisnevich G,Yudovitch L.Process for the preparation of dronedarone:WO,2003040120[P].2003-05-15.(CA 2003,138:385296).
  • 10Fino N,Leroy C.A process for the preparation of 2-butyl-5-[methanesulfonamido]benzofuran as an intermediate for the synthesis of dronedarone:WO,2002048132[P].2002-06-20.(CA 2002,137:33205).

引证文献7

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药学服务与研究
2008年 第6期

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