摘要
目的探讨肾小球肾炎患者外周血CD45-CD146+细胞的变化及意义。方法用流式细胞术检测25例肾小球肾炎患者和20例正常人群外周血细胞CD45-CD146+细胞数量。结果与正常对照组(2.07±0.86)个/μl比较,肾小球肾炎患者CD45-CD146+细胞数量(12.25±13.11)个/μl显著升高(t=3.459,P<0.05);②肾小球肾炎患者外周血CD45-CD146+细胞数量与中性粒细胞比例(P=0.00265,r=0.613)、BUN(P=0.00302,r=0.609)、Cr(P=0.00683,r=0.571)均呈正相关。结论CD45-CD146+细胞数量与肾小球肾炎的发生、严重程度密切相关。
Objective To study the clinical significance of measuring peripheral blood CD45^- CD146 ^+ cells in patients with glomerular nephritis. Methods CD45^- CD146^+ cells in peripheral blood were measured in 20 normal controls and 22 patients with glomerular nephritis by flow eytometry analysis. Results ①CD45^- CD146^+ number in patients with glomerular nephritis( 12.25±13.11个/uL) was obviously higher than that in normal control(2.07±0.86/uL) (t = 3. 459 P 〈 0.05);②CD45^- CD146^+ number in patients with glomerular nephritis was positively correlated with neutrophil ratio( P =0.00265, r =0.613), BUN( P = 0.00302, r = 0. 609) and Cr( P = 0. 00683, r = 0. 571). Conclusion These findings suggested that the changes of CD45^- CD146^+ numbers are closely related to the pathogenesis and severity of glomerular nephritis.
出处
《中国微循环》
北大核心
2008年第6期362-364,共3页
Journal of Chinese Microcirculation
基金
泰州市06年度科技社会发展计划项目(ts0604)