肾小球肾炎患者外周血CD45^-CD146^+细胞的检测及意义

The Clinical Significance of Measuring Peripheral Blood CD45^-CD146^+ Cells in Patients with Glomerular Nephritis

目的探讨肾小球肾炎患者外周血CD45-CD146+细胞的变化及意义。方法用流式细胞术检测25例肾小球肾炎患者和20例正常人群外周血细胞CD45-CD146+细胞数量。结果与正常对照组(2.07±0.86)个/μl比较,肾小球肾炎患者CD45-CD146+细胞数量(12.25±13.11)个/μl显著升高(t=3.459,P<0.05);②肾小球肾炎患者外周血CD45-CD146+细胞数量与中性粒细胞比例(P=0.00265,r=0.613)、BUN(P=0.00302,r=0.609)、Cr(P=0.00683,r=0.571)均呈正相关。结论CD45-CD146+细胞数量与肾小球肾炎的发生、严重程度密切相关。

Objective To study the clinical significance of measuring peripheral blood CD45^- CD146 ^＋ cells in patients with glomerular nephritis. Methods CD45^- CD146^＋ cells in peripheral blood were measured in 20 normal controls and 22 patients with glomerular nephritis by flow eytometry analysis. Results ①CD45^- CD146^＋ number in patients with glomerular nephritis（ 12.25±13.11个/uL） was obviously higher than that in normal control（2.07±0.86/uL） （t = 3. 459 P 〈 0.05）;②CD45^- CD146^＋ number in patients with glomerular nephritis was positively correlated with neutrophil ratio（ P =0.00265, r =0.613）, BUN（ P = 0.00302, r = 0. 609） and Cr（ P = 0. 00683, r = 0. 571）. Conclusion These findings suggested that the changes of CD45^- CD146^＋ numbers are closely related to the pathogenesis and severity of glomerular nephritis.