Alzheimer病与血管性痴呆患者认知功能对照研究

A comparision of cognition with Alzheimer`s disease and vascular dementia

目的探讨Alzheimer病与血管性痴呆患者认知功能状况及其之间差异。方法对36例临床诊断的Alzheimer病、35例血管性痴呆患者及35例健康人进行了事件相关电位(ERP)和简易智力状态检查(MMSE)测试。结果Alzheimer病组、血管性痴呆组ERP测定的异常率为94.4%(34/36)和85.7%(30/35),两组ERP中N2、P3波潜伏期较正常对照组延长,P3波幅降低,其差异具有统计学意义(P<0.01);而Alzheimer病组ERP测定N2、P3波潜伏期较血管性痴呆组延长,P3波幅降低,其差异具有统计学意义(P<0.05)。Alzheimer病组、血管性痴呆组MMSE量表总分值与分量表得分值较正常组降低,差异具有统计学意义(P<0.01,P<0.05);Alzheimer病组与血管性痴呆组比较,在MMSE量表总分、时间定向及物体命名等分值明显降低,差异具有统计学意义(P<0.05)。结论Alzheimer病与血管性痴呆患者均存在明显的认知功能减退,且Alzheimer病认知损害更为明显。

Objective To explore the condition and difference of cognition between Alzheimer＇s disease and vascular dementia. Methods Totally 36 Alzheimer＇s disease （AD） patients, 35 vascular dementia （VD） patients and 35 healthy persons（ control group） were studied. All the cases were assessed with event-related potential（ERP） and mini-mental state examination（MMSE） ,and the results were compared among the three groups. Results The abnormal rate of ERP inf AD group and VD group were 94.4% （34/36） and 85.7% （ 30/35 ）. The latency of N2 and P3 of ERP and the amplitude of P3 with the two groups were longer and lower than those in the controls. The latency of N2 and P3 of ERP and the amplitude of P3 in AD group were significantly longer and lower than those in VD group（ P 〈0.05 ）. The scores of total and sev-scale of MMSE with AD group and VD group were significantly lowr than those in control group（ P 〈 0.01 ,P 〈 0.05 ）. The scores of total,time orientation,name of object in MMSE in AD group were significantly lower than those in VD group（P 〈0.05）. Conclusion AD and VD patients have obvious cognitive impairment,and AD patient＇s changes more obviously.