摘要
目的:观察曲美他嗪(TMZ)治疗扩张型心肌病(DCM)患者的疗效。方法:选择56例DCM患者随机分为治疗组和对照组各28例。对照组:常规给予洋地黄类制剂、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂及β-阻滞剂等药物。治疗组:在常规治疗基础上加用TMZ(20mg tid)连服6个月。结果:两组心功能较治疗前有明显改善,治疗组临床总有效率为95.3%,较对照组(82.6%)显著提高(P<0.05),超声心动图各项指标改善(P<0.05)。病情恶化减少(P<0.05)。结论:长期服用TMZ可使DCM患者心功能改善且安全有效。
Objective： To observe the clinical therapeutic effect of trimetazidine （TMZ） on Dilated Cardiomyopathy （DCM）. Methods： 56 patients with DCM were randomly divided into TMZ treated group （n=28） and routine treated group （n=28）.And the TMZ group received TMZ （20mg 3 times per day）for 6 month. All the DCW patients were prescribed digitalis, diuretics, vasodilators, ACEI and β-blocker.Results：Heat function were conspicuous improved between TMZ group and routine treated group after treat, clinical effective percentage of TMZ group is 95.3%,there were elevsted obviously （P 〈0.05） than routine group （82.6%）. Condusion： Patients with DCM received TMZ for long time can improve heat function, it was safety and effective.
出处
《中国医药导刊》
2008年第9期1399-1400,共2页
Chinese Journal of Medicinal Guide
关键词
扩张型心肌病
心力衰竭
曲美他嗪
Dilated Cardiomyopathy
Heart failure
Trimetazidine
