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ω-3多不饱和脂肪酸对结肠癌的影响 被引量：6

Effects of ω-3 Polyunsaturated Fatty Acids on Colon Cancer
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摘要 ω-3多不饱和脂肪酸(ω-3PUFA)主要来源于鱼油,是细胞结构和功能重要组成成分,对细胞免疫应答调节和抑制发挥重要作用。ω-3PUFA可通过影响细胞膜脂质组成、调控脂类代谢水平及细胞内基因编码等多种途径,阻滞结肠癌细胞生长周期、抑制细胞增殖、促进细胞分化和诱导癌细胞凋亡,显著抑制结肠癌生长和转移,还可改善肿瘤恶病质患者体质,提高其存活率。 Omega-3 polyunstaurated fatty acids （ω-3PUFA） , mainly derived from fish oils, are essential for the integrity and function of the cells and play a key role as immune response modulators and suppressors of immunologic functions, ω-3PUFA can effectively inhibit the growth and metastasis of colon cancer by inhibiting cell proliferation, promoting cell differentiation, and inducing tumor cell apoptosis by profoundly altering the biochemical make-up of cell membrane lipid composition, regulating the level of lipid metabolism, and modulating the expression of intracelluar genes encoding, ω-3PUFA may also improve the patient＇s immunologic functions and increase the survival rate.
作者 刘敬武 尉承泽
机构地区 军事医学科学院附属
出处 《中国临床营养杂志》 2008年第6期371-376,共6页 Chinese Journal of Clinical Nutrition
关键词 Ω-3多不饱和脂肪酸 结肠癌 抑制 ω-3 polyunsaturated fatty acids colon cancer inhibition
分类号 R735.35 [医药卫生—肿瘤]
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参考文献28

  • 1Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds [ J ]. Curr Opin Gastroenterol, 2007, 23 ( 1 ) :48-54.
  • 2Mayer K, Meyer S, Reinholz-Muhly M, et al. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans [J]. J Immunol, 2003, 171(9) :4837-4843.
  • 3Chapkin RS, Davidson LA, Ly L, et al. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer [J]. Nutr, 2007, 137(3) :S200-S204.
  • 4Zhao Y, Chen LH. Eicosapentaenoic acid prevents lipopolysaccharide- stimulated DNA binding of activator protein-1 and c-Jun N-terminal kinase activity [ J]. J Nutr Biochem, 2005, 16(2) :78-84.
  • 5Kohno H, Yamaguchi N, Ohdoi C, et al. Modifying effect of tuna orbital oil rich indocosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt loci in rats [J]. Oncol Rep, 2000, 7(5) :1069-1074.
  • 6Huang YC, Jessup JM, Forse RA, et al. n-3fatty acids decrease colonic epithelial cell proliferation in high-risk bowel mucosa [J]. Lipids, 1996, 31(Suppl):S313-S317.
  • 7Collett ED, Davidson LA, Fan YY, et al. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in coloncytes [ J ]. Am J Physiol Cell Physiol, 2001, 280(5 ) : 1066-1075.
  • 8Turner ND, Zhang J, Davidson LA, et al. Oncogenic ras alters sensitivity of mouse coloncytes to butyrate and fatty acid mediated growth arrest and apoptosis [ J ]. Cancer Lett, 2002, 186( 1 ) :29-35.
  • 9Denys A, Hichami A, Khan NA. n-3PUFAs modulate T-cell activation via protein kinase C-α and -ε and the NF-κB signaling pathway [ J ]. Lipid Res, 2005, 46 (6) :752-758.
  • 10Murray NR, Weems C, Chen L, et al. Protein kinase C beta-Ⅱ and TGF beta R Ⅱ in omega-3 fatty acid-mediated inhi- bition of colon carcinogenesis [J]. Cell Biol, 2002, 157 (6) :915-920.

二级参考文献9

  • 1MACMICKING J,XIE Q W,NATHAN C.Nitric oxide and macrophage function[J].Annu Rev Immunol,1997,15:323.
  • 2DUKE T,SOUTH M,STEWART A.Activation of the L-arginine nitric oxide pathway in severe sepsis[J].Arch Dis Child,1997,76(3):203.
  • 3BERTERO M T,CALIGARIS-CAPPIO F.Anemia of chronic disorders in systemic autoimmune diseases[J].Haematologica,1997,82(3):375.
  • 4OHATA T,FUKUDA K,TAKAHASHI M,et al.Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids[J].Jpn J Cancer Res,1997,88(3):234.
  • 5LEE J Y,PLAKIDAS A,LEE W H,et al.Differential modulation of Toll-like receptors by fatty acids:preferential inhibition by n-3 polyunsaturated fatty acids[J].J Lipid Res.2003,44(3):479.
  • 6NOVAK T E,BABCOCK T A,JHO D H,et al.NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated maerophage TNF-alpha transcription[J].Am J Physiol Lung Cell Mol Physiol,2003,284:L84.
  • 7WATARU K,KENJI I,MASAKAZU M.et al.Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-γ plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress[J].Free Radic Biol Med,2003,34(8):1006.
  • 8CHEN L H,ZHAO Y.Eicosapentaenoic acid decreases lipopolysaccharide-stimulated tumor necrosis factor-a expression by inhibiting nuclear factor-κB activation[J].FASEB J,2001,15:A258.
  • 9邱海波,陈德昌.一氧化氮生物作用的两面性与多器官功能障碍综合征[J].基础医学与临床,1998,18(1):11-14. 被引量：27

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中国临床营养杂志
2008年 第6期

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