摘要
目的:探讨联合检测尿转铁蛋白(TRF)、α1-微球蛋白(α1-MG)和血半胱氨酸蛋白酶抑制剂C(Cystatin C)对糖尿病肾病(DN)早期诊断的临床意义。方法:64例2型糖尿病患者根据尿白蛋白排泄率(UAER)分为3组,A组为正常白蛋白尿组(UAER≤20μg/min)22例,B组为微量白蛋白尿组(UAER 20～200μg/min)19例;C组为大量白蛋白尿组(UAER≥200μg/min)23例。收集并测定各组患者24 h尿微量白蛋白、TRF、α1-MG,同时检测血清肌酐及Cystatin C,比较各组患者指标的变化。结果:与A组相比,B组和C组TRF、α1-MG和血Cystatin C均显著增高,联合检测阳性率明显高于单项检测。结论:联合检测TRF、α1-MG和血Cystatin C可以反应DN的早期损害,有利于早期诊断。
Objective：To explore vα1ue of combined measurement of urinary transferrin （TRF）, α1 - MG and serum cystatin C in diagnosing the early phase of diabetic nephropathy （DN）. Methods：Sixty- four DN patients were divided into three groups according to their 24 h urinary α1bumin excretion rate （UAER） ：group 1 （normα1 α1buminuria） ,group 2 （microα1buminuria） ,group 3 （macroα1buminuria）. Urinary micro α1bumins, TRF, α1 - MG, serum creatinine （Scr） and serum cystatin C were measured, and these indexes among three groups were compared. Results：The levds of urinary TRF, α1 - MG and serum Cystatin C in group 2 and group 3 were significantly higher than that in group 1. Co - detection of urinary TRF, 1 - MG and serum Cystatin C may have significantly higher positive rate than single one. Conclusion：Co - detection of urinary TRF, α1 - MG and serum cystatin C may indicate early renal damage in DN, and it is vα1uabe in diagnosing DN in the early phase.
出处
《中国中西医结合肾病杂志》
2008年第12期1065-1067,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
上海市自然科学基金资助项目(No.05ZR14086)
上海市医苑新星基金资助项目(No.02XX46)
