脑钠素在老年慢性心功能不全患者血浆水平的研究

Research of plasma level of BNP in elderly patients with congestive heart failure

目的探讨脑钠素在老年慢性心功能不全患者血浆水平的研究。方法选择心力衰竭患者89例,常规使用强心利尿及联合应用血管转换酶受体抑制剂等治疗。于治疗前后分别测定血浆脑钠素水平,使用美国HP5500型超声心动图仪测定心功能。30例健康作为对照。结果心功能不全组血浆脑钠素水平显著高于对照组(P<0.001),与心衰严重程度有关,左室射血分数显著低于对照组(P<0.01),血浆脑钠素水平于左室射血分数呈负相关(P<0.05),心力衰竭患者在治疗后,血浆脑钠素显著下降(P<0.05).EF分数提高(P<0.05)。结论血浆脑钠素(between brain natriuretic peptide,BNP)水平作为评价老年慢性心功能不全治疗效果的敏感指标。

Objective To explore the plasma level of brain natriuretic peptide （BNP） in patients with elderly congestive heart failure （CHF）. Methods Eighty nine CHF patients were treated with diuretic and angiotensin-converting enzyme inhibitor. The plasma levels of BNP were detected before and after treatment and cardiac function were measured by Doppler echocardiography. Thirty normal people were enrolled for control. Results Compared with control group, the levels of plasma BNP in CHF patients elevated significantly （ P 〈 0. 001 ）, and the left ventricular ejection fraction （EF） increased significantly （ P 〈 0.01 ）. The level of plasma BNP negatively correlated with EF in CHF patients （ P 〈 0.05 ）. The level of plasma BNP and EF in CHF patients had significant differences before and after treatment （ P 〈 0.05 ）. Conclusion Plasma BNP level has a relationship with cardiac function and it maybe a good biomarker to evaluate the cardiac function of CHF patients.