肝病患者血清叶酸与维生素B12含量的临床意义

Clinical significance of serum folic acid and vitamin B12 levels in patients with liver disease

目的探讨肝病患者血清叶酸（FA）与维生素B12（VitB12）含量的变化及其临床意义。方法应用微粒子化学发光免疫分析技术（CLIA）检测315例肝病患者及84例健康对照者的血清FA和VitB12含量，并对检测数据进行统计学分析。结果急性肝炎组血清FA含量与对照组比较，差异无统计学意义（P〉0．05），但其VitB12含量明显高于对照组（P〈0．05）。慢性肝炎轻度组血清FA、VitB12含量与对照组相比，差异无统计学意义（P〉0．05）。慢性肝炎中度组血清FA、VitB12含量与对照组相比，差异有统计学意义（P〈0．05）。慢性肝炎重度组、肝炎后肝硬化组、原发性肝癌组的FA含量均低于对照组（P〈0．01），VitB12含量均高于对照组（P〈0．01）。结论血清FA、VitB12含量变化与肝细胞病损程度密切相关，其检测结果对肝脏疾病的诊断、治疗及预后判断具有重要的临床价值。

Objective To study the correlation between the disease and the levels of folio acid （FA） and vitamin B12（VitB12） in serum. Method FA and VitB12 in serum of 315 patients and 84 controlled subjects were measured by CLIA. Results were carried out through statistic analysis. Results The levels of FA in acute hepatitis group had no statistical difference with that in the control group（ P 〉 0.05）, but the levels of VitB12 were higher than that in the control group（ P 〈 0. 05 ）. The levels of FA and VitB12 in mildly chronic hepatitis group had no statistical difference with the control group（ P 〉 0.05）. The levels of FA and VitB12 in moderately ehronie bepalitis had statistical difference with the control group （ P 〈 0.05）. The levels of FA in serious chronic hepatitis, cirrhosis of liver and liver cancer group were lower than that in the control group （ P 〈 0.01 ）, but the levels of VitB12 were higher than that in the control group obviously（ P 〈 0.01）. Conclusions FA and VitB12 level detection have very important clinical signifieanee in the diagnosis, therapy and prognosis of liver diseases.