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基质金属蛋白酶9在慢性鼻窦炎中的表达 被引量：2

Expression of matrix metallprotease-9 gene in chronic rhinosinusitis
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摘要 目的探讨基质金属蛋白酶9在慢性鼻窦炎组织中的表达情况。方法采用逆转录-聚合酶链反应方法和免疫组化方法检测65例慢性鼻窦炎患者鼻窦黏膜组织中基质金属蛋白酶9的mRNA和蛋白表达情况。结果基质金属蛋白酶9在慢性鼻窦炎组织表达较正常鼻下甲黏膜组织增高。无论在mRNA水平还是蛋白水平的相对表达量均随着慢性鼻窦炎的病程发展显著增加,呈正相关。结论基质金属蛋白酶9的表达增高,可能是促进慢性鼻窦炎发展和复发的一个重要因素。 Objective To investigate the expression of matrix metallprotease-9 gene in chronic rhinosinusitis tissues. Methods Reverse transcriptase polymerase chain reaction and immunohistochemistry methods were used to examine the expression of MMP-9 gene in 65 chronic rhinosinusitis tissues. Results The expressions of MMP-9 protein and mRNA in chronic rhinosinusitis tissues were increased compared with that in inferior turbinate mucosa tissues. The expression of MMP-9 was found to be positively related with the progress of chronic rhinosinusitis. Conclusion The increased expression of MMP-9 may be an important factor in promoting the progress and recrudescence of chronic rhinosinusitis.
作者 刘鸣 田霖丽 孙亚男 郭彦玲
机构地区 哈尔滨医科大学第二临床医学院耳鼻咽喉科
出处 《哈尔滨医科大学学报》 CAS 北大核心 2008年第6期619-621,共3页 Journal of Harbin Medical University
关键词 基质金属蛋白酶9 慢性鼻窦炎 鼻息肉 逆转录聚合酶链反应 matrix metallprotease-9 chronic rhinosinusitis nasal polyps RT-PCR
分类号 R765.41 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献5

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二级参考文献8

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共引文献11

同被引文献24

  • 1陆翔,刘争,崔永华.转化生长因子β_1和基质金属蛋白酶及其组织抑制物在慢性鼻窦炎和鼻息肉组织中的差异性表达[J].临床耳鼻咽喉科杂志,2005,19(14):633-635. 被引量：12
  • 2Bhandari A,Takeuchi K,Suzuki S,et al.Increased ex-pression of matrix metalloproteinase-2 in nasal polyps[J].ActaOtolaryngol,2004,124(10):1165-1170.
  • 3Lechapt-Zalcman E,Coste A,d'Ortho MP,et al.In-creased expression of matrix metalloproteinase-9 in nasal pol-yps[J].J Pathol,2001,193(2):233-241.
  • 4Chen YS,Langhammer T,Westhofen M,et al.Relation-ship between matrix metalloproteinases MMP-2,MMP-9,tis-sue inhibitor of matrix metalloproteinases-1 and IL-5,IL-8in nasal polyps[J].Allergy,2007,62(1):66-72.
  • 5Eisenberg G,Pradillo J,Plaza G,et al.Increased ex-pression and activity of MMP-9 in chronic rhinosinusitis withnasal polyposis[J].Acta Otorrinolaringol Es,2008,59(9):444-447.
  • 6Topal O,Erbek SS,Kiyici H,et al.Expression of metal-loproteinases MMP-2 and MMP-9 in antrochoanal polyps[J].Am J Rhinol,2008,22(4):339-342.
  • 7Lee YM,Kim SS,Kim HA,et a1.Eosinophil inflamma-tion of nasal polyp tissue:relationships with matrix metallopro-teinases,tissue inhibitor of meta11oproteinase-1,and transfor-ming growth factor-betal[J].J Korean Med Sci,2003,18(1):97-102.
  • 8Wang LF,Chien CY,Tai CF,et al.Matrix MMP-9gene polymorphisms in nasal polyposis[J].BMC Med Genet,2010,11(9):85-91.
  • 9Ling-Feng Wang,Chen-Yu Chien,Wen-Rei Kuo,et al.Matrix Metalloproteinase-2 Gene Polymorphisms in NasalPolyps[J].Arch Otolaryngol Head Neck Surg,2008,134(8):852-856.
  • 10Bousquet J, Jacot W, Vignola AM, et al. Allergic rhinitis: a disease remodeling the upper airways? J Allergy Clin Immunol, 2004, 113: 43-49.

引证文献2

二级引证文献18

哈尔滨医科大学学报
2008年 第6期

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