P73、c-Abl蛋白在卵巢肿瘤组织中的表达及临床意义

Expression of P73 and c-Abl proteins in ovarian carcinomas and its clinical significance

目的研究P73、c-Abl蛋白在卵巢肿瘤组织中的表达情况及相互关系,探讨其在卵巢肿瘤发生、发展中的作用。方法应用免疫组化SP法检测61例卵巢恶性肿瘤、28例卵巢交界性肿瘤和30例卵巢良性肿瘤组织中P73、c-Abl蛋白的表达情况。结果P73蛋白在卵巢良性、交界性、恶性肿瘤组织中的表达呈逐渐增高趋势;卵巢恶性肿瘤内P73蛋白的表达与组织分化有关,在低分化癌中有较高表达;卵巢癌患者中P73蛋白阴性表达者的生存期明显长于阳性表达者;c-Abl蛋白在卵巢良性、交界性、恶性肿瘤组织中的表达有显著差异(P<0.01),在卵巢癌中呈高表达;P73蛋白和c-Abl蛋白在卵巢癌中呈正相关性高表达(P<0.01)。结论p73基因以高表达方式参与卵巢癌的发生发展过程,卵巢癌中P73蛋白的高表达与c-Abl蛋白的高表达有关。P73蛋白的表达强度能够反映卵巢癌的恶性程度,可作为判断肿瘤生物学行为的参数和卵巢癌预后的指标。

Objective To investigate the expressions of P73 and c-Abl in ovarian tumors and the relationship of the expressions with the development of ovarian tumors. Methods The expressions of P73 and c-Abl proteins in 61 cases of malignant ovarian tumor,28 cases of borderline ovarian tumor and 30 cases of benign ovarian cancer was analyzed with immunohistochemisty technique. Results There were obvious differences of P73 expression among the three groups （P 〈 0.01 ）, the expression were gradually higher in order of benign ovarian tumor, borderline ovarian tumor and malignant ovarian tumor. The expression of P73 was correlated with the differentiation of malignant ovarian tumor and it had higher expression in cases of lower differentiation （ P 〈 0.05 ）. As P73 being negative, the survival time of patients were much longer （P 〈 0.01 ）. Expressions of c-Abl were obvious different among benign ovarian tumor, borderline ovarian tumor and malignant ovarian tumor （ P 〈 0.01 ） , and high in ovarian cancer. P73 expression had positive correlation with e-Abl expression （P 〈 0.01 ）. Conclusion p73 gene is involved in the development of ovarian cancer, the over expression of P73 is related with the expression of c-Abl. The intensity of P73 expression represents the grade of ovarian cancer,it is an important parameter for estimating biological behavior of tumor and a predictable factor in diagnosing ovarian cancer.