X连锁凋亡抑制蛋白在卵巢肿瘤中的表达及意义

Expression of X-Linked Inhibitor of Apoptosis Protein in Ovarian Tumors

目的:探讨X连锁凋亡抑制蛋白(XIAP)在卵巢上皮性肿瘤中表达的意义。方法:采用免疫组织化学技术分别检测30例良性上皮性卵巢肿瘤、41例卵巢上皮性癌和10例正常卵巢组织中XIAP的表达水平。结果:卵巢上皮性癌中XIAP表达率(95.1%)高于良性上皮性卵巢肿瘤的表达率(80.0%),差异有统计学意义(χ2=3.9623,P<0.05),且XIAP表达随临床分期的增高而增加(χ2=4.261,P<0.05)。XIAP弱阳性和阴性表达患者生存预后好于强阳性表达者(Log-rankχ2=4.92,P<0.05)。结论:XIAP在卵巢肿瘤组织中广泛表达,XIAP高表达可能促进卵巢肿瘤的发生和发展,可能会作为预后不良的标志。

Objective： To study the expression of X-linked inhibitor of apoptosis protein （XIAP） in the epithelial ovarian tumor and its clinical significance. Methods： The levels of XIAP were tested by immunohistoehemical technique in 30 specimens of benign ovarian tumors,41 specimens of epithelial ovarian carcinomas and 10 specimens of normal ovaries. Flesults： The expression of XIAP in epithelial ovarian carcinomas was significantly higher than in benign ovarian tumors （P〈 0.05）. The expression of XIAP in epithelial ovarian carcinomas was markedly increased during progression from early to advanced tumour clinical stages （P 〈 0.05）. The patients with higher expression of XIAP had unfavourable prognosis than those with lower or negative expression （Log-rank χ^2=-4.92, P 〈 0.05）. Conclusion： In epithelial ovarian carcinomas tissue, the expression of XIAP are abundant. The high level of XIAP is the poor prognostic factor in epithelial ovarian carcinomas. XIAP may play an important role in the occurrence and the progression of ovarian carcinoma.