老年急性缺血性脑血管病患者出现轻度认知功能损害的预测研究

Predictors of mild cognitive impairment after acute cerebral ischemia in elderly patients

目的探讨老年急性缺血性脑血管病患者出现轻度认知损害的相关危险因素,并建立概率预测模型。方法选择收治的87例老年急性缺血性脑血管病患者,对可能影响其认知功能水平的危险因素进行多元Logistic回归分析。结果患者年龄、文化程度、起病时临床神经功能缺损程度、病灶数量、伴发高血压、糖尿病等为影响患者发病后出现轻度认知损害的危险因素(P<0.05)。其中年龄、神经缺损程度和病灶数量是危险暴露因子,高血压和糖尿病病史则是保护因子。结论建立的认知功能损害概率预测模型对老年急性缺血性脑血管病患者出现轻度认知损害的治疗和护理具有一定的指导意义。

Objective To determine risk factors associated with mild cognitive impairment after acute cerebral ischemia in elderly patients and to develop its predictive model. Methods The data of 87 patients with acute ischemic cerebrovascular disease were retrospectively reviewed. Independent risk factors of influencing cognitive function were determined using multivariate logistic regression analyse. Results Univariate analysis found age, education level, at the onset of clinical neurologic defect, the number of lesions, associated with hypertension and diabetes to be significantly correlated with mild cognitive impairment after acute cerebral ischemia（P〈0.05）. Age,nerve defect extent and number of lesions were significant independent dangerous predictors, hypertension and diabetes were significant independent protective predictors of mild cognitive impairment. Conclusions Age, nerve defect extent, number of lesions,hypertension history and diabetes history is a powerful and ease-to-use predictor of mild cognitive impairment after acute cerebral ischemia in elderly patients.