单侧肾功能严重受损者^99Tc^m-二亚乙基三胺五乙酸肾动态显像测定对侧肾肾小球滤过率的临床意义

^99Tc^m-diethylenetriaminepenta hydroxamic acid renal dynamic imaging to evaluate split renal GFR of unilateral renal function failure patient

目的探讨^99Tc^m-二亚乙基三胺五乙酸（^99Tc^m-DTPA）肾动态显像在单侧肾脏功能严重受损患者中的应用。方法应用^99Tc^m-DTPA肾动态显像，测定82例单侧。肾脏功能严重受损患者的对侧肾脏肾小球滤过率（GFR），并将其与血清肌酐（SCr）值进行相关性分析，同时对对侧肾脏功能受损的病因进行分析。结果对侧肾GFR与SCr值呈负相关（r=-0．643，P〈0．001）；在一侧肾脏功能严重受损患者中，肾结石和泌尿系移行细胞肿瘤患者的对侧肾脏易受损害。结论单侧肾脏功能严重受损患者有必要通过^99Tc^m-DTPA肾动态显像密切观察对侧肾脏情况，以便及时治疗，防止对侧肾功能的衰竭。

Objective To explore the use of evaluating split glomerular flow rate （GFR） in patients with unilateral renal function failure by ^99Tc^m-diethylenetriaminepenta hydroxamic acid renal dynamic imaging. Methods Split GFR of 82 cases with unilateral renal function failure was evaluated by ^99Tc^m- DTPA renal dynamic imaging, and was correlated with serum ereatinine （SCr） . Beside, causes of renal function failure were analyzed. Results Split GFR were negatively correlated with SCr（r=-0.643, P〈0.001）. In the cases with unilateral renal function failure, renal calculi and urinary transitional cell carcinoma were mainly causes to injure the renal function. Conclusion It is very important of evaluating split GFR in patients with unilateral renal function failure by ^99Tc^m-DTPA renal dynamic imaging to treat early and reserve renal function.