摘要
乳腺癌是我国妇女最常见的恶性肿瘤之一，也是妇女中除肺癌外病死率最高的恶性肿瘤，早期诊断是降低乳腺癌病死率的关键因素。目前，乳腺癌的诊断方法主要是钼靶X线乳腺摄影、超声检查、磁共振成像、细针穿刺活组织检查等。乳腺癌的基因变化导致癌肿血流增加，葡萄糖代谢、氨基酸转运、蛋白质合成、受体表达增加，DNA合成和细胞增殖活跃，并诱导细胞凋亡。PET结果显示，肿瘤部位对^18F-氟脱氧葡萄糖（^18F-FDG）和^11C-甲硫氨酸（^11C—MET）摄取均增高而^11C-MET合成方便快捷，价格较^18F-FDG低，其在乳腺癌中的应用价值国外已有诸多报道。
Breast cancer is one of the most ordinary malignant tumors in woman, and its mortality is only less than that of lung cancer. Early diagnosis is a key to reducing the mortality rate. The commonly used methods to diagnose breast cancer include mammography, ultrasonography, magnetic resonance imaging. Genetic changes of breast cancer comprise increased tumor blood flow, increased levels of glucose metabolism, amino acid transport, protein synthesis receptor expression, enhanced DNA synthesis and cell proliferation, and induction of apoptosis. It shows high ^18F-fluorodeoxyglucose（^18F-FDG） or methionine uptake in breast cancer, ^11C-methionine （^11C-MET） has a lower price. PET with ^11C-MET has a high prognostic value in breast cancer.
出处
《国际放射医学核医学杂志》
2008年第5期299-301,共3页
International Journal of Radiation Medicine and Nuclear Medicine
