丹酚酸B与三七总皂苷不同配比对大鼠离体心脏冠脉流量的影响

Effect of different matching of salvianolic Acid B and panax Pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats

[目的]探讨丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量的影响。[方法]应用均匀设计的方法,将丹酚酸B与三七总皂苷的不同配比设计为6个水平,应用Langendorff系统进行离体心脏恒压灌流,记录6组实验给药前后大鼠的冠脉流量。[结果]丹酚酸B与三七总皂苷在升高大鼠冠脉流量上不存在线性回归关系,6组实验中以1号实验丹酚酸B/三七总皂苷为20mg/30mg升高大鼠冠脉流量最佳。[结论]丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量有很大影响。

[Objective] To explore the effect of different matching of salvianolic acid B combined with and panax pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats. [Methods] Six levels of different matching of salvianolic acid B and panax pseudo-ginseng total saponin were designed. Constant pressure perfusion of isolated heart was carried out by using Langendorff system and the coronary artery flow rate was recorded. [Results] There wasn＇t linear regression relation in enhancing coronary artery flow rate when salvianolic acid B and panax pseudo-ginseng total saponin were used. The 20 mg：30 mg dosage group was the best for increasing the coronary artery flow rate in rats. [Conclusion] Different matching of salvianolie acid B and panax pseudo-ginseng total saponin has a tremendous effect on coronary artery flow rate of isolated heart in rats.