鹿茸再生及干细胞研究进展

Research progress in deer antler regeneration and stem cells

鹿茸是哺乳动物中惟一能再生的器官,也是再生医学和干细胞研究的热点领域,将成为一个很好的生物医学研究模型。鹿茸的再生是基于干细胞,自身的干细胞受到刺激而发生增殖与分化,与肢体发育有相似之处的发育模式,不同于蝾螈的再生。鹿茸发育的调控模式、鹿茸干细胞生长机制对于肢体再生医学、干细胞研究具有重要的意义。很多科学家对鹿茸进行了深入的研究,提出了很多理论假说。文章对鹿茸发育领域鹿茸再生和鹿茸干细胞的研究成果进行汇总分析,介绍了鹿茸发育领域的研究技术及其相关理论基础。

Deer antlers are the unique mammalian organs that can be periodically regenerated, i.e., they hold interest for researchers on stem cells and regenerative medicine, and have the potential to become an excellent biomedical research model. Deer antler regeneration may use stem cells. Antler growth appears to involve specific stimulation of the necessary stem cells present in the locality, and involves similar mechanisms to those used in limb development, unlike the regenerative process in the newt. Development regulation of antler and growth mechanism of antler stem cells have significance in limb regenerated medicine and stem cell research. Many scientists have carried out thorough research on the deer antlers development, thus, have drawn many concepts. This article reviews the field of deer antlers development such as antler regeneration and stem cells, and introduces research technique of antler development and relevant theories.