低能激光照射及嗅鞘细胞移植在脊髓损伤中的应用

Application of low power laser irradiation and olfactory ensheathing cell transplantation in treatment of spinal cord injury

脊髓损伤是一种严重危害人类健康的疾病,因其少突胶质细胞不能形成轴突迁移引导的通道,并分泌抑制因子,以及星形胶质细胞在损伤区快速反应性增生形成胶质瘢痕,抑制轴突的生长,使脊髓损伤的治疗成为目前医学领域的一个棘手问题。嗅鞘细胞具有良好的轴突再生和准确形成靶特异性突轴连接的能力;低能激光照射对神经系统及嗅鞘细胞的作用包括,保留甚至促进受损神经元的活性,减少瘢痕的形成,阻止神经元的退行性改变,又能通过干拢一些因素而增强嗅鞘细胞的活性。嗅鞘细胞移植及低能激光照射在脊髓损伤的修复中具有重要的作用。

Spinal cord injury has been considered the disease seriously suffering people. Their oligodendrocyte cells cannot form the channel guide to axons＇ migrating and secrete inhibitors, as well as astrocytes format glial scar in the injured district after rapidly reactive proliferation and inhibit axon growth. Thus, the treatment of spinal cord injury is still a thorny issue in medical field at present. Olfactory ensheathing cells have a good specific process axis linking of axon regeneration and accurately target. The effects of low power laser irradiation on the nervous system and olfactory ensheathing cells not only included its reservations and even promotion of the activity of damaged neurons, decrease in scar formation, prevention of the degeneration of neurons, but also increase in olfactory ensheathing cell activity by intervening some factors. Olfactory ensheathing cell transplantation and low power laser irradiation play an important role in the repair of spinal cord injury.