丙型肝炎感染患者对体外受精与胚胎移植结局的影响

Effect of C hepatitis on outcome of in vitro fertilization and embryo transfer

目的探讨丙型肝炎病毒(HCV)感染的不育/不孕患者对体外受精与胚胎移植(IVF-ET)治疗结局的影响。方法回顾性分析2000年1月至2005年12月在中山大学附属第一医院生殖中心接受IVF-ET治疗的丙肝病毒感染不育/不孕症患者资料。A组为女方丙型肝炎患者共37例50周期,B组为男方丙型肝炎患者共30例36周期;C组为对照组无HCV感染患者共78例100周期。结果A组患者临床妊娠率及种植率较B组和C组显著下降,而流产率明显升高(P均<0.05)。A组患者子代活产儿中有2例检测HCV-RNA阳性。结论感染HCV的女性患者在进行IVF-ET前应予充分知情同意,并告知对IVF-ET治疗结局的影响和子代存在病毒感染的可能性。

Objective To analyze the impact of the hepatitis C virus （ HCV ） infection on the outcome of in vitro fertilization and embryo transfer （IVF-ET）. Methods A retrospective study was performed in infertile patients who were divided by C hepatitis infection or not. Group A was 50 cycles and 37women with C hepatitis infection,group B was 36 cycles and 30 men with C hepatitis infection and group C was 100 cycles and 78 patients without C hepatitis infection,which was as a controlling group. Results Compared with B and C group,women with C hepatitis infection had significant lower clinical pregnancy rate and implantation rate,but early aborted rate and total aborted rate remarkablly increased （ P 〈 0.05 ） in group A comparing with those in group B and group C. There were 2 off-springs infected with C hepatitis in group A. Conclusion The adverse effects on the outcome of in vitro fertilization and embryo transfer（IVF-ET） should be given to patients with C hepatitis infection before treatment. C hepatitis infection in women could cause vertical transmission.