体外反搏治疗小儿难治性癫痫远期疗效观察

Long-term curative effects of external counterpulsation on children intractable epilepsy

目的探讨体外反搏术治疗小儿难治性癫痫的远期疗效。方法对9例难治性癫痫患儿在原用抗癫痫药物(AEDs)不变的基础上,辅佐体外反搏治疗,每次持续60 min,每10天为1个疗程,共6个疗程。观察体外反搏治疗前后发作频率的改变及远期随访疗效、不良反应,以及对脑电生理及癫痫灶局部脑血流的影响。结果体外反搏治疗组治疗后癫痫发作明显减少,治疗组9例患儿跟踪随访2年,其中5例未见癫痫发作,2例癫痫发作明显减少,1例无效;对照组1例未见癫痫发作,2例癫痫发作次数减少,5例无效。体外反搏治疗后脑血流灌注好转率达77.8%,痫性放电现象明显减少,转阴率55.6%。两组疗效比较,差异具有统计学意义(P<0.01)。结论体外反搏治疗小儿难治性癫痫疗效肯定,远期疗效显著。

Objective To explore the effects of external counterpulsation on children intractable epilepsy. Methods On the basis of conventional antiepileptic drugs, 9 cases of children with.intractable epilepsy received 6 courses of adjuvant external eounterpulsation, 60 minutes per day, 10 days as a course. The frequency of seizure pre and post treatment , long - term follow - up results, adverse reactions, brain electrophysiology and the regional blood flow in the epilepsy foci were observed. Results The frequency of seizure in the group treated with external eounterpulsation decreased evidently. 5 cases of 9 patients had no seizure, the frequency of seizure decreased evidently in 2 cases and 1 case had no effect in the following 2 years. While 1 case in the control group had no seizure, the frequency of seizure decreased in 2 cases and 5 cases had no effect. Improvement rate of brain blood flow perfusion reached 77.8% , epileptic discharge decreased evidently with negative rate of 55.6%. The difference of efficacy between two groups was significantly（ P 〈 0.01 ）. Conclusion External eounterpulsation play a definite role in the therapy of children intractable epilepsy and has long- term significant curative effect.