还原型谷胱甘肽治疗多种病因肝损害疗效及安全性评价

Clinical Study on Safety and Efficacy of Reduced Glutathione in Treating Patients with Multipathogenesis-induced Hepatic Injury

目的评估还原型谷胱甘肽治疗多种病因肝损害的效果及安全性。方法采用随机和对照的临床设计,将204例多种病因肝损害患者随机分为治疗组和对照组,以临床症状和肝功能作为疗效的主要评判指标,同时观察患者药物治疗后的不良反应。结果治疗组接受还原型谷胱甘肽治疗后总有效率明显高于对照组(分别是88.57%和73.74%,P<0.01);不良反应两组间差异无显著性,均无发生不良事件。结论还原型谷胱甘肽能有效改善肝功能,具有较好的安全性和耐受性,适用于多种病因导致的肝损害。

Objective To evaluate the therapeutic efficacy, tolerability and safety profiles of reduced glutathione in the treatment of multipathogenesis- induced hepatic injury. Methods Total 204 patients with multipathgenesis- induced hepatic injury were included, and divided into two groups randomly, reduced glutathione group and without reduced glutathione group respectively. There was no significant difference between the two groups in pretreatment clinic data. The main parameters to valuate the efficacy were liver function and clinical symptom. The side effects were intensively observed. Results The efficacy in reduced glutathione group was significant higher than that without reduced glutathione group（88.57% and 73.74%, P〈0.01）. There was no significant difference between the two groups in the sideeffects. No severe side- effects were observed in both two groups. Conclusion Reduced glutathione can improve liver function and have good tolerance and safety profiles. It is good to application in multipathogenesis- induced hepatic injury.