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自然杀伤T细胞配基的研究进展 被引量：3

Investigation Progress of NKT Cell Ligands
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摘要 自然杀伤T细胞（NKT）在抗感染、抗肿瘤及自身免疫病中起保护作用，NKT细胞配基对NKT细胞的激活起关键作用。近年来NKT细胞配基的分离、鉴定、结构与功能研究取得了较大进展，本文就已鉴定的内源性和外源性NKT细胞配基的结构及其生物学功能研究进展予以综述。 Active Natural killer T （NKT） cells play a protective role against infectious diseases, cancers,and autoimmune diseases,while NKT cell ligands play a key role in the activation of NKT. Progress has recently been made in the researches of the isolation, identification, structure and function of the NKT cell ligands. This paper reviewed the progress of endogenous and exogenous NKT cell ligands.
作者 陆田田 黄震 陈章权
机构地区 广东医学院临床免疫学教研室
出处 《医学综述》 2009年第1期22-24,共3页 Medical Recapitulate
基金 广东省中医药局中医药强省科研基金(1060043)
关键词 CD1D 自然杀伤T细胞 配基 CD1d NKT cell Ligand
分类号 Q51 [生物学—生物化学]
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参考文献18

  • 1Zajonc DM, Cantu C 3rd, Mattner J,et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor [J]. Nat Immunol,2005,6(8) :810-818.
  • 2Fujii S, Shimizu K, Hemmi H, et al. Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice [ J ]. PNAS, 2006, 103 (30) :11252-11257.
  • 3Xing GW, Wu D, Poles MA, et al. Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides [ J ]. Bioorg Med Chem,2005,13 ( 8 ) :2907-2916.
  • 4Oki S,Chiba A, Yamamura T, et al. The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells [ J ]. J Clin Invest, 2004, 113 (11) :1631-1640.
  • 5Chang YJ, Huang JR, Tsai YC, et al. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids [ J ]. PNAS ,2007,104 (25) :10299-10304.
  • 6Koch M, Stronge VS, Shepherd D,et al. The crystal structure of human CD1 d with and without alpha-galactosylceramide[ J ]. Nat Immunol,2005,6 ( 8 ) :819-826.
  • 7Toba T,Murata K, Nakanishi K, et al. Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokiue induction and the discovery of non-linear phytosphingosine analogs[J]. Bioorg Med Chem Lett,2007,17(10) :2781-2784.
  • 8Fujio M,Wu D,Garcia-Navarro R,et al. Structure-based discovery of glycolipids for CD1 d-mediated NKT cell activation: tuning the adjuvant versus immunosuppression activity[ J ]. J Am Chem Soc, 2006,128 ( 28 ) :9022-9023.
  • 9Wu D,Zajonc DM, Fujio M, et al. Design of natural killer T cell activators:Structure and function of a microbial glycosphingolipid bound to mouse CD1 d[ J]. PNAS ,2006,103 ( 11 ) :3972-3977.
  • 10Ben-Menachem G, Kubler-Kielb J, Coxon B,et al. A newly discovered cholesteryl galactoside from Borrelia burgdorferi [ J ]. PNAS, 2003,100( 13 ) :7913-7918.

同被引文献29

  • 1Bin Ling,Fengqiu Yao,Ying Zhou,Zhengzheng Chen,Guodong Shen,Yuanyuan Zhu.Cell-Mediated Immunity Imbalance in Patients with Intrahepatic Cholestasis of Pregnancy[J].Cellular & Molecular Immunology,2007,4(1):71-75. 被引量：19
  • 2Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J. CDld-lipid-antigen recognition by the semi-invariant NKT T-cell receptor[J]. Nature, 2007,448(7149) :44-49.
  • 3Mattren J, Debord K, Ismail N, Goff R, Contu C, Zhou D, Saint Mezard P, Wang V, Gao Y, Yin N, Hoeba K, Schneewind O, Walker D. Exogenous and endogenous glycolipid antigen activate NKT cells during microbial infections[J]. Nature, 2005,434 (7032) : 525 - 529.
  • 4Naoe M, Ogawa Y, Takeshita K, Morita J, Iwamoto S, Miyazaki A, Yoshida H. Bacillus Calmette-Guerin-pulsed dendritic cells stimulate natural killer T cells and gamma deltaT cells[J]. Int J Urol,2007,14(6) :532-538.
  • 5Tsao TC, Chen CH, Hong JH, Hsieh MJ, Tsao KC, Lee CH. Shifts of T4/T8 T lymphoeytes from BAL fluid and peripheral blood by clinical grade in patients with pulmonary tuberculosis [J]. Chest, 2002,122(4):1285-1291.
  • 6中华医学会.临床诊疗手册(结核病分册)[M].北京:人民出版社,2005:80.
  • 7American Thoracic Society. Targeted tuberculin testing and treatment of latent tuberculosis infection [J]. Am J Respir Crit Care Med, 2000,161(8) :S221-S247.
  • 8Kulpraneet M, Sukwit S, Sumransurp K, Chuenehitra T, Santiwatanakul S, Srisurapanon S. Cytokine production in NK and NKT cells from Mycobacterium tuberculosis infected patients [J]. Southeast Asian J Trop Med Public Health, 2007,38(2) : 370 -375.
  • 9Gansert J. L, Kieler V, Engele M, Wittke, Rollinghoff M, Krensky AM, Porcelli S, Modlin R. L, Stenger S. Human NKT cells express granulysin and exhibit antimycobacterial ac tivity[J]. Immunol, 2003,170(6): 3154-3161.
  • 10Sugawara I, Yamada H, Mizuno S, Li C Y, Nakayama T, Taniguc M. Mycobacterial infection in natural killer T cell knockout mice[J]. Tuberculosis, 2002,82(2) :97-104.

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医学综述
2009年 第1期

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