摘要
CD105是一个特异表达于新生血管内皮的糖蛋白，主要标记具有增殖活性的内皮细胞。肿瘤生长和浸润有赖于血管生成，新生的血管提供给肿瘤组织营养及氧分．为肿瘤组织增殖提供了基础。CD105是肿瘤新生血管的标志物，其标记的微血管密度，优于其他标志物，更能反映肿瘤的增殖状态和预后，血管生成是肿瘤生长和转移的推动力，以CD105为靶向，抑制肿瘤血管生长的治疗胂瘤的方法成为目前研究的热点。
CD105 is a kind of glycoproteins idio-expressed in the neogenetic vessel endothelium, which always marks the cells with proliferation activity. Tumor＇s growth and invasion depend on angiogenesis. The neogenetic vessels supply nutrition and oxygen to tumor and provide foundation for tissue proliferation. CD105 is the marker of new vessels in tumor by marking the microvessel density,which is better than any other marker in reflecting the proliferation state of tumor and its prognosis. Angiogenesis is the promoter for tumor gowth and metastasis. Now it is a hot spot in studying the CD105 targeted therapeutic method by inhibiting tumor＇s vascularization.
出处
《医学综述》
2009年第1期68-70,共3页
Medical Recapitulate
