重症急性胰腺炎的肠道黏膜屏障改变与肠源性感染

Changes of Intestinal Mucosal Barrier in Severe Acute Pancreatitis and Enterogenic Infection

重症急性胰腺炎患者最终往往死于继发的感染及驻器功能衰竭。感染来源多数认为是肠道细菌移位所致，而肠道细菌移位始动环节是肠道黏膜屏障受损。重症胰腺炎时肠道黏膜屏障功能障碍，从而引发肠道细菌及内毒素的移位、全身炎性反应及多器官功能障碍，严重影响患者的预后。

Severe acute pancreatitis patients often die from secondary infection and organ failure in the end. Most of the source of infection is caused by bacterial translocation ,and bacterial translocation often result from intestinal mucosal barrier damage. The intestinal mucosal barrier dysfunction in severe pancreatitis will result in the translocation of bacteria and endotoxin, and systemic inflammatory response and multiple organ dysfunction,which can affect the prognosis of patients.