胃液pH值与呼吸机相关性肺炎病原菌的关系

A study on the relationship between the PH value of gastric juice and the pathogenic bacteria of ventilator-associated pneumonia

①目的探讨不同胃液pH值情况下,呼吸机相关性肺炎(VAP)及其病原学的相关性。②方法收集98例合格的病例,对其测得的胃内pH值,下呼吸道标本的细菌进行培养,按VAP和无VAP分为两组,比较VAP组和无VAP组患者下呼吸道标本病原菌的种类与胃液pH值间的关系。③结果胃液pH值影响胃腔定植菌种类,当胃液pH≤4时胃腔定植菌主要为念珠菌和革兰阳性杆菌;胃液pH>4时,胃腔内革兰阴性杆菌分离率明显上升,VAP组显著高于无VAP组。④结论胃液pH值是影响胃腔定植菌,特别是革兰阴性杆菌定植的重要因素。

Objective To investigate the etiology of ventilator - associated pneumonia（VAP） in different PH valves. Methods Ninty - eight cases were chose in the ICU and divided into two groups ： VAP and non - VAP,then the PH values of gastric juice were measured and bacterium of lower respiratory tract were cultivated, and the relation was analysed between bacteria and PH values of gastric juice in two groups. Results The types of gastric colonized bacteria were affected by gastric PH. When the PH value of gastric juice was ≤4,the gastric colonized bacteria were mainly monilia and Gram positive bacilli, whereas the PH value of gastric juice was 〉 4, the isolation rate of Gram negative bacilli （GNB） was markedly increased, and which in VAP group was significant higher than that in non - VAP group. Conclusion The PH value of gasetric juice was the major factor affecting the colonization of bacteria, especially GNB.