舌下含化硝苯吡啶快速降压作用疗效分析

THERAPEUTIC EVALUATION OF QUICK ANTIHYPERTENSION OF SUBLINGUAL NIFEDIPINE

选择６２例收缩期血压（ＳＢＰ）２６．６７～３７．３ｋＰａ，舒张期血压（ＤＢＰ）１６．０～１８．６７ｋＰａ高血压病患者。立即舌下含化硝苯吡啶２０ｍｇ，观察该药短时间内快速降压效果，结果：３０ｍｉｎ内ＤＢＰ下降２．６７～３．３３ｋＰａ者５０例，占８０．６５％，６０ｍｉｎ内ＤＢＰ下降１．３３～３．６ｋＰａ及ＳＢＰ下降３．３３～１０．９３ｋＰａ者各５８例，占９３．５５％。无效者４例，占６．４５％。在治疗观察中，发现该药对充血性心力衰竭也有一定作用，１２例心衰中经含化该药１～２ｈ后，有９例（７５％）患者临床症状得到明显改善，心率由原来平均１０１次／ｍｉｎ，降至９２次／ｍｉｎ。由于该药具有扩张小动脉降低后负荷，同时也有扩张静脉作用，短时间降压速度快，可口服及舌下含化。因此，该药可作为重症高血压或高血压急症应急性药物，对并发有急性充血性心力衰竭患者也极为有益。

In this paper,62 cases hypertensive patients were selected whose systolic pressure (SP) is 26.67～37.3Kpa and diastolic pressure (DP) is 16.0～18.67 Kpa,then they were given 20mg Nifedipine to observe the quick antihypertension effect in a short course.The result shows as follows.There were 50 cases whose DP had declined 2.67～3.33 Kpa in 30 min (80.65%) and 58 cases whose DP had declinded 1.33～3.6Kpa and SP declined 3.33～10.93 Kpa in 60 min (93.55%),only 4 cases no effect (6.45%).The observer also finds that nifedipine has some effect on congestive heart failure. In that the clinical symptoms of 9 cases heart failure patient is obviously improved of 12 cases patients after sublingually nifedipine 1～2 hours,whose heart rate declines from 101/min to 92/min.Generally,the drug can enlarge arteriole and vein to decline the afterload,So the antihypertension is quick.On the whole,the drug not only can act as emergency medicine for severe hypertension and hypertensive emergency,but also has much help for acute congestiue heart failure..