摘要
应用酶联免疫双抗夹心法对７８例胃癌患者血清可溶性白介素２－受体（ｓＩＬ－２Ｒ）和肿瘤坏死因子－α（ＴＮＦ－α）进行临床观察。结果发现：胃癌患者血清ｓＩＬ－２Ｒ和ＴＮＦ－α水平明显高于胃良性疾病和正常人（Ｐ＜０．０１）；Ⅲ、Ⅳ期高于Ⅰ、Ⅱ期（Ｐ＜０．０１）；手术切除后（根治性或姑息性）ｓＩＬ－２Ｒ和ＴＮＦ－α显著下降（Ｐ＜０．０１）；手术后复发或转移患者血清中ｓＩＬ－２Ｒ和ＴＮＦ－α含量升高（Ｐ＜０．０１）；ｓＩＬ－２Ｒ和ＴＮＦ－α水平呈正相关（ｒ＝０．３３）；如果患者血清ｓＩＬ－２Ｒ含量高于１０００ｕ／Ｌ同时伴有ＴＮＦ－α持续高于１２０ｎｇ／ｍｌ，预兆生存期短。监测胃癌患者血清ｓＩＬ－２Ｒ和ＴＮＦ－α水平对临床诊断，病情估计和预后有重大意义。
? The serum soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-alpha (TNF-α) were measured by the enzyme-linked immunosorbent assay in 78 patients with gastric cancer.The results showed that the serum levels of sIL-2R and TNF-α were higher in patients with gastric cancer than those of normal and benign gastric diseases (all P<005);the serum levels of sIL-2R and TNF-α were markedly declined in the group with tumor removed (including both radical operation and palliative tumor resection) after operation (P<001). After tumor removal,the concentration of both sIL-2R and TNF-α were higher in patients with recurrence and metastasis than those without recurrence and metastasis (P<001).If the concentration of sIL-2R was more than1000u/ml and the concentration of TNF-α more than 120ng/ml in serum of patients,the prognosis was poor.There was a positive relationship between sIL-2R and TNF-α in gastric cancer (r=033,P<005).The results indicate that the serum levels of sIL-2R and TNF-α may play an important role in the pathogenesis of gastric cancer.Monitoring the serum levels of sIL-2R and TNF-α is beneficial to clinical diagnosis and prognosis.
