摘要
研究了３７例梗阻性黄疸（Ａ组）和１２０例单纯胆囊结石（Ｂ组）患者补体水平变化，Ａ组分为重症急性胆管炎（ＡＣＳＴ）急诊手术组（Ａ１组）和择期手术组（Ａ２组）。结果显示Ａ１、Ａ２组术前血清补体３（Ｃ３）水平显著低于Ｂ组（Ｐ＜０．０１），而循环免疫复合物（ＣＩＣ）水平显著高于Ｂ组（Ｐ＜０．０１）。手术后Ａ、Ａ１、Ａ２组Ｃ３显著高于术前，而ＣＩＣ显著低于术前。研究表明在梗阻性黄疸和胆道感染时肝细胞、巨噬细胞等Ｃ３产生减少，肝窦枯否细胞对ＣＩＣ清除功能降低。
Change of the serum complement level was studied in 37 patients with extrahepatic obstructive jaundice (growp A) and 120 cases with simple gallstones (group B).Group A was subgrouped into acute severe cholangitis group (A1) and elective operation group (A2).The results showed that the level of serum complement-3 (C3) was obviously lower in group A1、A2 than that of group B (p<0.01).And circulating immune complex (CIC) in the group A1、A2 was significantly higher than that of group B in preoperation.The level of serum C3 in postoperation was markedly higher than that in preoperation,but level of CIC in postoperation was lower than that in preoperation. The study indicated that production of C3 in hepatocytes,macrophages,etc was decreased.The clearance of CIC in liver Kupffer cells with obstructive jaundice or biliary infection was also decreased.
