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胰腺导管腺癌细胞起源的探讨 被引量：2

The Cellular Origin of Pancreatic Ductal Adenocarcinoma
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摘要 胰腺导管腺癌形态学特征是由不同分化程度的导管样结构构成。近年研究发现胰腺内的导管细胞、腺泡细胞或胰岛细胞能够从一种细胞形态转分化(transdifferentiation)形成另一种细胞形态,因此提出了不同的观点,认为胰腺内导管、腺泡、胰岛或胰腺的前体干细胞都可能是进展成胰腺导管腺癌的起源细胞,使鉴定胰腺导管腺癌的细胞起源变得非常复杂。明确胰腺癌的细胞起源能够更好地认识肿瘤起始时的分子事件,有助于推动胰腺癌的早期诊断和治疗。
作者 倪晓光 赵平 王贵齐 刘尚梅
机构地区 中国医学科学院中国协和医科大学肿瘤医院
出处 《中国肿瘤》 CAS 2009年第1期42-45,共4页 China Cancer
基金 国家自然科学基金(30500582)
关键词 胰腺肿瘤 导管细胞 腺泡细胞 胰岛细胞 肿瘤干细胞
分类号 R730.23 [医药卫生—肿瘤] R735.9 [医药卫生—肿瘤]
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参考文献18

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共引文献5

同被引文献21

  • 1孟令新,李强,郭仁德,张毓青.裸鼠胰腺癌动物模型及其应用进展[J].中华实验外科杂志,2006,23(12):1583-1584. 被引量：18
  • 2黄生福,杨竹林,梁珊,李清龙,范文涛.胰腺癌大鼠胰腺上皮内瘤变的研究[J].中华实验外科杂志,2007,24(4):401-403. 被引量：3
  • 3张思维,陈万青,孔灵芝,李光琳,赵平.中国部分市县2003年恶性肿瘤发病年度报告[J].中国肿瘤,2007,16(7):494-507. 被引量：100
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引证文献2

二级引证文献8

中国肿瘤
2009年 第1期

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