Effect of aspirin on glucose-D transport in intestine of rat

Objective: The present study was designed to evaluate the effect a commonly prescribed Non Steroidal Anti Inflammatory Drug(NSAID) i.e.aspirin on brush border membrane in terms of changes in the intestinal transport level of glucose which is monosaccharide with absolute requirement in the body and hence its absorption is directly proportional on the morphology of the intestinal mucosa.Method: Albino rats(Rattus Norvegicus) were divided into two different groups,Group I(Control),Group II(aspirin-treated,50 mg aspirin/kg of body weight).The treatment was continued for 28 days.On the 29th day after overnight fasting,intestine was removed from animals of both groups.Changes in transport of glucose-D in intestine were studied.Result: The results indicated a significant decrease in the transport of glucose-D in aspirin treated group as compared to the control group.Conclusion: Cautious use of NSAID is recommended in commonly observed symptom such as headache and to those patients who are given as a prophylaxis for thrombosis.

Objective： The present study was designed to evaluate the effect a commonly prescribed Non Steroidal Anti Inflammatory Drug （NSAID） i.e. aspirin on brush border membrane in terms of changes in the intestinal transport level of glucose which is monosaccharide with absolute requirement in the body and hence its absorption is directly proportional on the morphology of the intestinal mueosa. Method： Albino rats （Rattus Norvegicus） were divided into two different groups, Group I （Control）, Group II （ aspirin-treated, 50 mg aspirin/kg of body weight）. The treatment was continued for 28 days. On the 29th day after overnight fasting, intestine was removed from animals of both groups. Changes in transport of glueose-D in intestine were studied. Result： The results indicated a significant decrease in the transport of glucose-D in aspirin treated group as compared to the control group. Conclusion： Cautious use of NSAID is recommended in commonly observed symptom such as headache and to those patients who are given as a prophylaxis for thrombosis.