摘要
Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia.Methods: The study was conducted on 55 newly diagnosed hyperlipidemic patients and 57 healthy controls.Serum paraoxonase activity and protein thiols were estimated by spectrophotometeric method and lipid profile by enzymatic kinetic assay method.Results: Serum paraoxonase activity,protein thiols and high density lipoprotein levels were low and total cholesterol,triglycerides and low density lipoprotein levels were high in patients with hyperlipidemia compared to healthy controls(P<0.01).Serum paraoxonase activity correlated positively with protein thiols and high density lipoprotein(P<0.01).Conclusion: Decreased paraoxonase activity and protein thiols were found in patients with hyperlipidemia.This may indicate the susceptibility of this population to accelerated atherogenesis and protein oxidation.
Objective: In the present study we evaluated the paraoxonase activity and protein thiols level in south Indian population with newly diagnosed hyperlipidemia. Methods: The study was conducted on 55 newly diagnosed hyplerlipidemic patients and 57 healthy controls. Serum paraoxonase activity and protein thiols were estimated by spectrophotometeric method and lipid profile by enzymatic kinetic assay method. Results: Serum paraoxonase activity, protein thiols and high density liPopretein levels were low and total cholesterol, triglycerides and low density lipoprotein levels were high in patients with hyperlipidemia compared to healthy controls (P〈 0.01 ). Serum paraoxonase activity correlated positively with protein thiols and high density lipoprotein (P〈0.01). Conclusion: Decreased paraoxonase activity and protein thiols were found in patients with hyperlipi- demia. This may indicate the susceptibility of this population to accelerated atherogenesis and protein oxidation.
出处
《海南医学院学报》
CAS
2009年第2期111-113,共3页
Journal of Hainan Medical University
关键词
血清磷酶
蛋白质
高血脂
临床分析
治疗方法
Paraoxonase, protein thiols, hyperlipidemia, high density lipoprotein.