2000-2006年中华骨髓库等待造血干细胞移植白血病患者的人口学及临床分布特征

Demographic characteristics of patients with leukemia waiting for stem cell transplantation in Chinese marrow donor program during 2000 to 2006

目的研究2000--2006年中华骨髓库中等待造血干细胞移植的白血病患者的分布特征和规律，为白血病的预防、干预提供科学依据。方法采用MicrosoftSQL2005数据库操作平台对3708例中国籍汉族白血病患者数据，分组计算患者年龄、性别、地区等分布曲线，并采用x2检验方法比较其分布差异。结果2000--2006年间，中华骨髓库中3708例白血病患者，年龄范围7个月至69岁，中位年龄为24．5岁，标准差为±6．7岁；男女患者总体比值1．95：1（2451／1257）；慢性粒细胞白血病（chronic myeloid leukemia，CML）患者1435例，急性淋巴细胞白血病（acute lymphoblastic leukemia，ALL）患者1202例，急性非淋巴细胞白血病（acute myeloid leukemia，AML）患者1066例，慢性淋巴细胞白血病（chronicly mphoblastic leukemia，CLL）患者5例，以CML最为多见；白血病患者的分布高峰值在15-岁至30～岁年龄组，15～岁年龄组542例，20-岁年龄组559例，25～岁年龄组514例，30一岁年龄组522例；20～岁以下年龄组（儿童组），其中ALL占49．36％（613／1242），AML占27．78％（245／1242），CML占22．78％（283／1242），CLL占0．08％（1／1242），以ALL患者构成比居多；白血病患者在我国30个地区的分布构成不均一，最低0例，最高494例，中位数101例。结论2000--2006年间，中华骨髓库中等待造血干细胞移植的白血病患者构成以儿童和青少年为主，男性高于女性，儿童白血病分类以ALL为主，应加强这一群体的健康教育和白血病防治工作。等待造血干细胞移植的白血病患者在各地区分布不均一，江苏、广东、浙江和山东地区患者有较高的分布格局。

Objective To explore the distributive characteristics for leukemia and to provide scientific reference for its prevention and intervention. Methods Microsoft SQL 2005 databases was used to make a mathematical analysis of 3708 patients with leukemia in Chinese Marrow Donor Program （CMDP） from 2000 to 2006. The distributive characteristics were calculated by sex, age and area of patients with leukemia and then compared by constituent ratio and relative ratio statistics method. Results A total of 3708 cases of leukemia were registered for waiting donor during the period 2000--2006 in CMDP, the age of patients were from 7 months to 69 years,the median age of diagnosis was 24. 5 years, standard deviation was 6.7 years old ; males suffered more than females,and the ratio was 1.95： 1（2451/1257）. There were 1202 patients with acute lymphoblastic leukemia（ALL）, 1066 with acute myeloid leukemia （AML）, 1435 with chronic myeloid leukemia （ CML）, 5 with chronic lymphoblastic leukemia（CLL） , CML was the most common patients. The distributive of 3708 patients with leukemia peak was from 15 to 30 years age group ,542 patients were at the age of 15 years,559 patients were at the age group above 20 years,514 patients were at the age above 25,522 patients were at the age over 30 years old. ALL patients were accounted for 49. 36% （613/ 1242）, AML patients accounted for 27.78% （ 245/1242 ）, CML patients accounted for 22.78% （ 283/ 1242 ）, CLL patients accounted for 0. 08% （1/1242） in the age group of under 20 years （childhood group）.All subjects were mainly in childhood patients with leukemia; The distributive of patients with leukemia in 30 areas were different, leukemia patients were not registered in one area ,494 patients were at the highest peak, 101 patients were in the median. Conclusion The majority of leukemia patients for waiting stem cell transplantation were registered among children and the adolescents groups, males were suffered more than the females. For children,the major type of leukemia was ALL, being necessary to pay more attention to the education of health, and the precaution of leukemia. The distributive of patients with leukemia for waiting stem cell transplantation was different in 30 areas, and the peak region of leukemia should be in Jiangsu, Guangdong, Shangdong, and Zhejiang provinces.