海水浸泡对烧冲复合伤犬血流动力学的影响

Influence of seawater immersion on hemodynamics in dogs after burn-blast combined injury

目的:建立犬烧冲复合伤后海水浸泡的实验模型,探讨海水浸泡对烧冲复合伤犬血流动力学的影响。方法:17只健康成年杂交犬随机分为两组,对照组:致烧冲复合伤后直接观察(n=7);浸泡组:致伤后置入21℃海水中浸泡4 h(n=10),于致伤前及伤后4 h、7 h、10 h、20 h、28 h测定血流动力学指标。结果:浸泡组出水后犬血流动力学各指标显著恶化,外周平均动脉压(MAP)、心脏指数(CI)、左室每搏功指数(LVSW I)等持续下降;而全身血管阻力指数(SVR I)随时间延长呈恢复趋势。对照组致伤前后多数血流动力学指标无显著变化。结论:海水浸泡可导致实验犬血流动力学状况明显恶化。

Objective： To evaluate the effects of seawater immersion on hemodynamics in dogs after burn - blast combined injury and establish a relevant experimental model. Methods： Seventeen healthy dogs were randomly divided into two groups. The dogs in the control group （ n = 7 ） only suffered burn - blast combined injury, while those in seawater immersion group （ n = 10） underwent seawater immersion after suffered burn - blast combined injury. Their hemodynamic changes were recorded before injury and at 4, 7, 10, 20, 28 h after injury, respectively. Results： MAP （ mean arterial blood pressure） , CI （ cardiac index ） and LVSWI （ left ventricular - stroke work index ） all decreased significantly in seawater immersion group compared with those in control group （ P 〈 0.05 ） ; and SVRI （ systemic vascular resistance index） had a tendency to recover with time passing. However, most of the hemodynamic indexes in control group did not change markedly before and after injury. Conclusion： Seawater immersion after burn - blast combined injury can worsen the hemodynamic status in dogs.