摘要
对２１例择期手术定位取材所获得的５例左右肝管汇合部狭窄、７例Ⅰ级肝管狭窄、７例Ⅱ级肝管汇合部狭窄、１０例Ⅱ级肝管狭窄及１０例Ⅲ级肝管狭窄标本进行Ⅲ、Ⅳ型胶原蛋白的免疫组化观察及定量分析。结果：正常胆管壁、门脉区及肝窦的Ⅲ型胶原呈浅淡而不连续的阳性染色，而狭窄胆管壁、门脉区及肝窦的Ⅲ型胶原则呈连续粗线状阳性染色，与正常对照组比较，其差异非常显著（Ｐ＜０．０１）；在有胆管狭窄处的肝窦部，Ⅳ型胶原呈连续粗线状阳性染色。
Immunohistochemical study on 39 specimens of hepatobilibary duct stricture due to stones were performed. Collagen types Ⅲ and Ⅳ were studied by quantitative analysis. The results showed that significant increase of type Ⅲ collagen was found in the stenotic bile duct wall, the portal area and liver sinusoid with fibrosis. Abnormal increasing of type Ⅳ collagen was found in the liver sinusoid of the stenotic bile duct.
出处
《中国普外基础与临床杂志》
CAS
1998年第2期75-77,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
胆管狭窄
肝纤维化
胶原蛋白
免疫组织化学
胆石
Bile duct stricture Liver fibrosis Collagen Immunohistochemistry Quantity
