慢性胆道梗阻时肝脏病理变化的立体学研究

Stereological Study of Pathological Changes of Liver in Chronic Biliary Obstruction

用立体学方法测得大鼠胆总管结扎后1W、2W、3W，其汇管区周围肝窦横径较对照组明显扩张（P＜0．01），增大幅度分别为67．34％、86．26％和94．81％。单位体积肝窦表面积较对照组明显减小（P＜0．01），减小幅度分别为31．07％、32．94％和36．21％。各结扎组中，肝细胞体积比较对照组肝细胞体积比减小（P＜0．05）；肝内纤维组织体积比较对照组肝内纤维组织体积比增加（P＜0．05）；肝内小血管体积比虽较对照组肝内小血管体积比增加，但无统计学差异（P＞0．05）。本实验证实：慢性肛道梗阻后肝内分流途径是汇管区周围扩张的肝窦。

The authors found,using stereological methods.that the sinusoids of rats in peri-Portal areadialated significantly one,two or three weeks after common bile duct ligation (CBDL),compared to control (P<0.01 ),and the dialating rates were 67. 34%, 86. 26% and 94. 81 % respectively. The surface area of sinusoids per unit volume decreased significantly in all 3 CBDL groups,compared to control (P<0.01),and thedecreasing rates were 31.07%, 32. 94% and 36. 21% respectively. The volume ratios of liver cells in 3 CBDLgroups decreased and the volume ratios of intrahepatic fibrous tissue increased significantly,compared to control (P<0.05). The volume ratios of intrahepatic small vessels in 3 CBDL groups increased slightly thanthat in control,but there were not statistically significant differences among them (P>0.05). The resultsconfirmed that the intrahepatic shunts, which deve1oped after CBDL, were dialated sinusoids in peri-portalarea.