孤独症与精神分裂症患者异常淋巴细胞的对照研究

Atypical lymphocyte in the free naive autistic children and first episode schizophrenia

目的了解孤独症患者免疫功能状况以及孤独症和精神分裂症在免疫指标上是否存在联系。方法采用随机、双盲法检测２４例孤独症和１５例精神分裂症患者外周血中的异常淋巴细胞。患者均未服过抗精神病药，精神分裂症为首次发作。结果孤独症和精神分裂症患者外周血中Ｐ型异常淋巴细胞分别为１２．７％±９．２％、１７．６％±８．７％，均较各自正常对照组（分别为３．２％±２．３％、５．１％±４．３％）显著增多（Ｐ＜０．０１），而孤独症组与精神分裂症组之间差异无显著性（Ｐ＞０．０５）。结论孤独症存在免疫功能异常。

Objective The aim of the paper was to investigate the immunological parameter of children with autism and to examine the relationship between autism and schizophrenia in view of immunological variable. Methods The atypical lymphocytes in the peripheral blood of patients with autism and schizophrenia were determined using a randomized, double blind design. Results P type atypical lymphocytes increased significantly in the peripheral blood of drug free patients with autism and never medication, first episode patients with schizophrenia, compared with their respective control groups. There was no significant difference in P type lymphocytes between autistic group and schizophrenic group. Conclusion The findings suggested that immune disturbance might be present in the subjects with autism, which was in accordant with viral hypothesis and autoimmune hypothesis.