情感性精神障碍不同亚型的预后比较

Prognosis of affective disorders in different subtypes

目的探讨情感性精神障碍亚型与预后的关系。方法对１１７例情感性精神障碍患者进行出院８年后的随访调查，并将其分为单相抑郁症（２５例）、双相非混合／快速循环型（６６例）和双相混合／快速循环型（２６例）３组。结果双相混合／快速循环型的复发、自杀和慢性化的发生率均高于其它两组，大体评定量表评分低于其它两组，社会功能缺陷筛选量表总分高于其它两组。结局评定显示，双相混合／快速循环型最差，双相非混合／快速循环型一般，单相抑郁症最好。

Objective The goal of this study was to study the prognosis of affective disorders in different subtypes. Methods 117 patients diagnosed as affective disorders were followed up at the eighth year after their discharge. They were divided into three groups of 25 unipolar depression, 66 bipolar non mixed/rapid cycling affective disorder and 26 bipolar mixed/rapid cycling affective disorder.Results The patients in bipolar mixed/rapid cycling group had significantly higher incidences of relapse, suicide and chronicity, and lower GAS score but higher SDSS total score compared with other two groups. The outcome assessment showed an poor outcome for patients with bipolar mixed/rapid cycling subtype, a moderate outcome for bipolar non mixed/rapid subtype and an good outcome for unipolar one. Conclusion The results suggest that bipolar mixed/rapid cycling subtype may be one with unfavourable prognosis in affective disorder.